Objective      To retrospectively analyze the perinatal and neonatal outcomes in 1 237 pregnancies through in vitro fertilization (IVF).  Methods      A total of 1 237 women who were pregnant in our center through IVF/intracytoplasmic sperm injection (ICSI) assisted pregnancy technologies (APT)  from January 2011 to July 2014 were enrolled in this study. They were assigned as APT group

including 711 cases of fresh embryo transfer cycles and 526 cases of frozen thawed embryo transfer cycle (FET). And another 5 040 cases of natural pregnancy in our hospital during the same period served as the control group. The perinatal and neonatal outcomes were compared among these groups. Results      The average age was 30.4±4.2 in the APT group

obviously older than that of the control group (P0.05). The APT group had significantly higher rates of multiple pregnancy and cesarean section than the control group (P0.05)

but remarkably shorter average gestational age and lower average body weight of the neonates (P0.05)

and obviously higher incidences of pregnancy hypertension (PIH)

placenta previa

pregnancy intrahepatic cholestasis (ICP)

postpartum hemorrhage

mother in ICU

hospitalized neonates

low birth weight infants

preterm delivery and neonatal ICU rate (NICU) (P0.05). There were no significant difference in the incidences of placental abruption

preeclampsia

premature rupture of membranes (PROM)

stillbirth

neonatal death and neonatal malformation between the APT and natural pregnancy groups. In the APT group

the fresh embryo group had significantly shorter gestational age and lower weight of newborn than the FET group (P0.05)

but there was no difference in the incidences of PIH

placenta previa

pre eclampsia

placental abruption

mother into ICU

stillbirth

neonatal death

hospitalized neonates

neonatal malformations

NICU and preterm delivery between them (P0.05). Conclusion      The incidences of PIH

placenta previa

ICP

postpartum hemorrhage

mother into ICU

hospitalized neonates

low birth weight infants

premature birth and NICU are higher in the APT group than the natural pregnancy group.