Objective       To investigate the multiple mediation effects of coping styles on the relationship between anxiety sensitivity (AS) and work-related fatigue among military personnel.  Methods      Anxiety sensitivity index Ⅲ (ASI-3)

simplified coping style questionnaire (SCSQ) and work related fatigue feeling questionnaire (WRFFQ) were surveyed in the soldiers of an army force

and 240 valid questionnaires were collected. The relationships between variables were analyzed by structure equation modeling.  Results      ①There were no statistically significant differences in workrelated fatigue of military personnel with respect to demographic factors such as service length

whether from single-child family

residence prior to army and education level (P0.05)

but significantly differences were seen in military rank level (soldiers/officers/cadres) [F(2

237)=3.087，P=0.047]. Soldiers and officers had a higher score of fatigue than cadres （9.22±3.78 vs 7.31±3.20，LSD-t=1.917，P=0.044；9.67±3.97 vs 7.31±3.20，LSD-t=2.365，P=0.014). ②Soldiers with high-AS scored higher in drowsiness

emotional anxiety

discomfort

tiredness

visual fatigue

and total score of WRFFQ compared with those with low-AS（P0.001）. ③Except for the correlation between negative and positive coping styles

both anxiety sensitivity’s score (the total score and each factor’s score) and coping styles (both positive and negative)  were strongly associated with the fatigue (P0.01). This correlation was able to predict fatigue significantly and explain 31.7% of the total variation. ④Multiple mediation modeling and Bootstrap test showed that the anxiety sensitivity had indirect effects on fatigue through the mediation effects of negative and positive coping styles（χ2/df=1.836， P=0.076， GFI=0.984， AGFI=0.951， NFI=0.979， RFI=0.955，IFI=0.990，TLI=0.979，CFI=0.990， RMSEA=0.059）. The mediation effect of negative and positive coping styles were 18.2% and 18.2%

respectively

and the total mediation effect was 36.4%.    Conclusion     Both the negative and positive coping styles exert multiple medication effects on the relationship between anxiety sensitivity and workrelated fatigue. More attention should be paid to the fatigue of high-AS individuals

helping them to modify their coping styles in order to avoid the declined efficiency in performance.