Conventional magnetic resonance imaging (MRI) sequences are largely nonspecific in the pathology they reveal

and provide a limited view of the complex morphological changes associated with gliomas. For the purpose of clinical application

advanced MR imaging promises to complement existing techniques by revealing more specific information on the changes of gliomas-relevant pathophysiology

such as cerebral microangiopathy and dysbolism. Moreover

genetic alterations in gliomas associated with unique phenotype signatures can be detected by advanced MRI. This relationship between MRI modalities and molecular features will facilitate diagnosis

patient stratification

and monitoring of treatment response. In this review

we outlined the current efforts to correlate advanced imaging findings with the genetic/histopathological development in gliomas

and discussed the challenges that were being encountered in this area afterwards.