Objective     To investigate the distributional characteristics of single nucleotide polymorphisms (SNPs) of apolipoproteins B (APOB) (rs693 CT)

low-density lipid receptor (LDLR) (rs688 CT)

and apolipoproteins C-Ⅰ (APOC-Ⅰ) (rs4420638 AG)

and explore their relationship with the blood lipid levels.    Methods      The gene polymorphisms of the 3 SNPs (rs693

rs688

rs4420638) were determined by polymerase chain reaction-high resolution melting (PCRHRM) in 462 subjects of Han nationality living in Lanzhou region. The relationship of the 3 SNPs with the blood lipid levels was analyzed.   Results       The genotype and allele frequencies of rs688

rs693 and rs4420638 were CC 64.9%

CT 32.5%

TT 2.6%

C 81.2% and T 18.8%; CC 87.0%

CT 13.0%

C 93.5% and T 6.5%; AA 85.7%

AG 14.3%

A 92.9%

and G 7.1%. Under dominant model

the multiple linear regression analyses were carried out by putting total cholesterol (TC)

triglyceride (TG)

low-density lipid-cholesterol (LDL-C) and high-density lipid-cholesterol (HDL-C) as the dependent variable

and gender

age

body mass index (BMI)

rs688 CT

rs693 CT

and rs4420638 AG as independent variables. The results showed that serum levels of TC and LDL-C of rs688 T allele carriers were significantly higher than homozygous type (β=0.301

P0.01; β=0.335

P0.01). The serum levels of TC and TG of rs693 T allele carriers were significantly lower than homozygous type (β=-0.250

P=0.027; β=-0.162

P=0.029). The TG levels of rs4420638 T allele carriers were significantly higher than homozygous type (β=0.180

P=0.016).      Conclusion      SNPs of rs688

rs693 and rs4420638 are significantly associated with blood lipid levels in Chinese Han population.