Correlation between microRNA206 single nucleotide polymorphisms and HBVrelated hepatocellular carcinoma

李天驹; 秦波; 李朋

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Correlation between microRNA206 single nucleotide polymorphisms and HBVrelated hepatocellular carcinoma

更新时间：2026-01-09

- Correlation between microRNA206 single nucleotide polymorphisms and HBVrelated hepatocellular carcinoma
- Journal of Army Medical University Vol. 38, Issue 16, Pages: 1843-1848(2016)
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  CLC： R373.21;R730.23;R735.7
- Published：2016
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李天驹,秦波,李朋.microRNA-206单核苷酸多态性与乙型肝炎病毒相关原发性肝癌关系的初步研究[J].陆军军医大学学报(原第三军医大学学报),2016,38(16):1843-1848.

　Li Tianju,Qin Bo,Li Peng.Correlation between microRNA206 single nucleotide polymorphisms and HBVrelated hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(16):1843-1848.
李天驹,秦波,李朋.microRNA-206单核苷酸多态性与乙型肝炎病毒相关原发性肝癌关系的初步研究[J].陆军军医大学学报(原第三军医大学学报),2016,38(16):1843-1848. DOI：

　Li Tianju,Qin Bo,Li Peng.Correlation between microRNA206 single nucleotide polymorphisms and HBVrelated hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(16):1843-1848. DOI：

摘要

目的探讨microRNA-206(miRNA-206)单核苷酸多态性与乙型肝炎病毒(HBV)相关原发性肝癌遗传易感性及术后复发的关系。方法共纳入三组受试对象，分别为128例HBV相关肝癌患者（HCC组）、121例慢乙肝患者（CHB组）及129例健康受试者（CON组）。采用生物信息学方法预测并筛选位于miRNA-206启动子调控区域的三个标签SNP，基质辅助激光解吸电离飞行时间质谱法检测miRNA-206 rs16882131、rs6920648、rs945210三个SNP位点的基因型，分析其与HBV相关肝癌易感性及早期复发的关系。结果 miRNA-206 rs16882131基因型及等位基因分布在HCC、CHB、CON三组间差异有统计学意义，其突变基因型CC和等位基因C降低HBV相关肝癌发生风险(OR=0.354，95% CI 0.163～0.771；OR=0.182，95% CI 0.124～0.267)，但与肝癌术后早期复发无显著相关性。结论 miRNA-206 rs16882131多态性可能与HBV相关肝癌遗传易感性相关，但与肝癌术后早期复发无明显关系。

Abstract

Objective To investigate the correlation of microRNA-206 (miRNA-206) single nucleotide polymorphisms (SNPs) with genetic predispostion and early recurrence after resection of HBV-related hepatocellular carcinoma (HCC). Methods A total of 378 subjects

including 128 patients with HBV-related HCC (HCC group)

121 patients with chronic hepatitis B (CHB group) and 129 normal controls (control group)

were enrolled in this study. Bioinformatics methods were used to predict and screen 3 SNPs (rs16882131

rs69020648

rs945210) in miRNA-206 gene promoter regulatory region

and matrix-assisted laser desorption ionization time of flight mass spectrometry analysis was adopted to detect the genotypes of the 3 SNPs in miRNA-206 gene. The correlation between genetic variants and the risk of HCC was analyzed

and the impact of mutations on HCC early recurrence was assessed. Results The distributions of genotypes and alleles of miRNA-206 rs16882131 were significantly different among the 3 groups. The CC genotype and C allele were associated with reduced risk of HCC (OR=0.354

95%CI: 0.163~0.771; OR=0.182

95% CI: 0.124~0.267). Conclusion MiRNA-206 rs16882131 polymorphism may be associated with the genetic predispostion of HBV-related HCC

but not associated with the early reccurence of HCC.

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