Effect of evodiamine on <sup>18</sup>F-FDG uptake in mouse brain and interscapular brown adipose tissue

冯悦; 钟萌; 张莉; 朱艳; 邱琳; 陈跃

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Effect of evodiamine on ¹⁸F-FDG uptake in mouse brain and interscapular brown adipose tissue

更新时间：2026-01-09

- Effect of evodiamine on ¹⁸F-FDG uptake in mouse brain and interscapular brown adipose tissue
- Journal of Army Medical University Vol. 38, Issue 15, Pages: 1746-1749(2016)
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  CLC： Q591.4;R285.5;R322.81
- Published：2016
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冯悦,钟萌,张莉,朱艳,邱琳,陈跃.吴茱萸碱对小鼠大脑及肩胛间棕色脂肪摄取18F-FDG的影响[J].陆军军医大学学报(原第三军医大学学报),2016,38(15):1746-1749.

　Feng Yue,Zhong Meng,Zhang Li,Zhu Yan,Qiu Lin,Chen Yue.Effect of evodiamine on 18F-FDG uptake in mouse brain and interscapular brown adipose tissue[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(15):1746-1749.
冯悦,钟萌,张莉,朱艳,邱琳,陈跃.吴茱萸碱对小鼠大脑及肩胛间棕色脂肪摄取18F-FDG的影响[J].陆军军医大学学报(原第三军医大学学报),2016,38(15):1746-1749. DOI：

　Feng Yue,Zhong Meng,Zhang Li,Zhu Yan,Qiu Lin,Chen Yue.Effect of evodiamine on 18F-FDG uptake in mouse brain and interscapular brown adipose tissue[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(15):1746-1749. DOI：

摘要

目的利用小动物PET/CT观察吴茱萸碱（evodiamine，EVO）对小鼠大脑及肩胛间棕色脂肪（interscapular brown adipose tissue，IBAT）糖代谢的影响。方法采用完全随机分组法将昆明小鼠分为5组，分别腹腔注射剂量为0（空白组）、125、250、375 mg/kg的EVO混悬液，30 min后腹腔注射

F-氟代脱氧葡萄糖（

F-FDG），1 h后采用小动物PET/CT观察各组小鼠大脑及IBAT摄取

F-FDG的情况，并测定其标准化摄取值(SUV)。结果 5组小鼠IBAT的SUV值分别为（0.81±0.08）、（0.53±0.06）、（1.30±0.17）、（1.70±0.10）和（0.74±0.21）。剂量为250 mg/kg和375 mg/kg时，IBAT的SUV值与空白组比较明显升高（P0.05）。5组小鼠大脑SUV值分别为（1.43±0.15）、（2.20±0.20）、（2.80±0.20）、（3.33±0.15）和（4.00±0.25），随EVO剂量增加而升高，组间比较差异均有统计学意义（P0.05）。结论 EVO可以增加小鼠IBAT和大脑的糖代谢。

Abstract

Objective To study the effect of evodiamine (EVO) on glucose metabolism of brain and interscapular brown adipose tissue (IBAT) in mice quantified by 18F-fluoro-deoxyglucose (

F-FDG) positron emission tomography (PET)/computed tomography (CT) scanning. Methods Kunming mice were randomized into 5 groups (each group n=3) and intraperitoneal (i.p.) injected with EVO doses of 0

125

250

375 and 500 mg/kg

and

F-FDG was given in 30 min later. The upta

ke of

F-FDG in the brain and IBAT were observed after 1 h and standard uptake value (SUV) were measured by micro-PET/CT. Results The SUVs of IBAT were 0.81±0.08

0.53±0.06

1.30±0.17

1.70±0.10 and 0.74±0.21 corresponding to EVO doses of 0

125

250

375 and 500 mg/kg. Compared to the control

the increased SUVs in the groups of 250 and 375 mg/kg were significant (P0.05). The SUVs of brain were 1.43±0.15

2.20±0.20

2.80±0.20

3.33±0.15 and 4.00±0.25

in a dose-dependent manner. Difference between each 2 groups was statistically significant (P0.05). Conclusion EVO enhances glucose metabolism in mice IBAT and brain.

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Effect of evodiamine on 18F-FDG uptake in mouse brain and interscapular brown adipose tissue

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references

Effect of evodiamine on ¹⁸F-FDG uptake in mouse brain and interscapular brown adipose tissue