Objective      To research the similarities and differences of flash electroretinogram (FERG)

pattern electroretinogram (PERG)

flash visual-evoked potential (FVEP) and pattern visual evoked potential (PVEP) between the normal macaques and human.       Methods      The data of FERG

PERG

FVEP and PVEP of normal human group (n=8

16 eyes) and normal macaque group (n=3

6 eyes) were measured by fundus photography and optical coherence tomography and recorded. The experiment data was analyzed with SPSS 13.0.       Results      The peaking time and amplitude of dark-adapted 0.01 ERG b wave and 3.0 ERG a wave and b wave of normal macaques were shorter and lower than those of normal human (P0.05)

and the amplitude of OS2 wave of Ops reaction of the normal macaque group was also lower than that of the normal human group. There were no statistical differences in the peaking time and amplitude of 3.0 ERG a wave and b wave and 30 Hz flicker ERG between the normal macaque group and normal human group. The peaking time of FVEP P2 wave of the normal macaque group was shorter than that of the normal human group

while the amplitude of FVEP P2 wave of the normal macaque was apparently higher (P0.05). The amplitude of PERG P50 and N95 wave of the normal macaques was obviously lower than that of the normal human (P0.05). The amplitude of PVEP P100 wave of the normal macaques was lower than that of the normal human group (P0.05)

and no significant difference was observed in the peaking time of PVEP P100 wave.       Conclusion      Electroretinography and visual evoked potential can be used to evaluate the visual function of macaques as retinal disease animal mode.