Correlation of XRCC1 Arg 399Gln polymorphism with acute irradiation injury of cervical cancer: report of 152 cases

蓝美玲; 肖何; 余娴; 张志敏; 张辉; 何轩; 李建; 周鹏; 叶云飞; 王阁

您当前的位置：

首页 >

文章列表页 >

Correlation of XRCC1 Arg 399Gln polymorphism with acute irradiation injury of cervical cancer: report of 152 cases

更新时间：2026-01-09

- Correlation of XRCC1 Arg 399Gln polymorphism with acute irradiation injury of cervical cancer: report of 152 cases
- Journal of Army Medical University Vol. 38, Issue 9, Pages: 1010-1014(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R394.3;R730.55;R737.33
- Published：2016
- 稿件说明：
移动端阅览
蓝美玲,肖何,余娴,张志敏,张辉,何轩,李建,周鹏,叶云飞,王阁.X线修复交错互补基因1-Arg399Gln多态性与宫颈癌急性放射性损伤的相关性[J].陆军军医大学学报(原第三军医大学学报),2016,38(09):1010-1014.

　Lan Meiling,Xiao He,Yu Xian,Zhang Zhimin,Zhang Hui,He Xuan,Li Jian,Zhou Peng,Ye Yunfei,Wang Ge.Correlation of XRCC1 Arg 399Gln polymorphism with acute irradiation injury of cervical cancer: report of 152 cases[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(09):1010-1014.
蓝美玲,肖何,余娴,张志敏,张辉,何轩,李建,周鹏,叶云飞,王阁.X线修复交错互补基因1-Arg399Gln多态性与宫颈癌急性放射性损伤的相关性[J].陆军军医大学学报(原第三军医大学学报),2016,38(09):1010-1014. DOI：

　Lan Meiling,Xiao He,Yu Xian,Zhang Zhimin,Zhang Hui,He Xuan,Li Jian,Zhou Peng,Ye Yunfei,Wang Ge.Correlation of XRCC1 Arg 399Gln polymorphism with acute irradiation injury of cervical cancer: report of 152 cases[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(09):1010-1014. DOI：

摘要

目的探讨X线修复交错互补基因1(X-ray repair cross complementing group 1，XRCC1)-Arg399Gln多态性与宫颈癌急性放射性损伤的相关性。方法收集经病理活检证实为宫颈癌的患者152例。Sanger测序法检测外周血XRCC1基因单核苷酸多态性(single nucleotide polymorphism

SNP)，并分析其与急性放射性损伤致放射性膀胱炎和直肠炎发生的关系。结果 152例宫颈癌患者中，携带XRCC1 Arg/Arg、Arg/Gln、Gln/Gln基因型的分别有78、56、18例。其中发生2～3级急性膀胱炎有47例；2～3级急性直肠炎有100例，没有4级膀胱炎、直肠炎的发生。对其他临床因素校正后，多变量Logistic回归分析表明XRCC1 399密码子杂合变异基因型携带者(Arg/Gln)和纯合变异携带者(Gln/Gln)的2～3级膀胱炎发生风险显著高于野生型患者，分别为野生型的4.114倍(OR=4.114

95%CI:1.746～9.693)和9.096倍(OR=9.096

95%CI:2.707～30.566)；2～3级直肠炎发生风险分别是野生型的5.011倍(OR=5.011

95%CI:2.169～11.575)和7.165倍(OR=7.165

95%CI:1.506～34.092)。结论 XRCC1 399密码子的SNP与宫颈癌急性放射性膀胱炎和直肠炎有关，具有潜在的放射治疗副反应预测因子价值。

Abstract

Objective To investigate the correlation of the polymorphism of X-ray repair cross complementing group 1 (XRCC1) Arg399Gln with acute radiotherapy-induced injuries in cervical cancer. Methods A total of 152 patients with pathology-confirmed cervical cancer admitted in our hospital from July 2011 to June 2015 were recruited in this study. Single nucleotide polymorphisms (SNPS) in XRCC1 gene were analyzed by Sanger sequencing

and the results were evaluated with the occurrences of acute radiotherapy-induced cystitis and proctitis in the patients. Results In the cohort

there were 78

56 and 18 patients respectively carrying XRCC1 Arg/Arg

Arg/Gln

and Gln/Gln

and 47 cases of grade 2-3 acute cystitis

100 of grade 2-3 acute proctitis and none of grade 4 cystitis and proctitis. After adjustment for other clinical factors

multivariate logistic regression analysis indicated that the patients carrying XRCC1 399Arg/Gln and 399Gln/Gln had higher risk for the development of grade 2-3 cystitis when compared with those carrying wide type (OR=4.114

95%CI: 1.746～9.693; OR=9.096; 95%CI: 2.707～30.566)

and were prone to having of grade 2-3 proctitis (OR=5.011

95%CI: 2.169～11.575; OR=7.165; 95%CI: 1.506～34.092). Conclusion SNPs of XRCC1 codon 399 is related with acute radiotherapy-injured cystitis and proctitis in cervical cancer

and of potential predictive value for side effects of radiotherapy.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Construction and validation of prediction model for cervical cancer recurrence based on systemic inflammation response index and clinicopathological parameters

Value of DCE-MRI parameters for short-term prognosis of pharyngeal cancer after postoperative radiotherapy

Efficacy of different jaw widths in volumetric modulated arc therapy for cervical cancer

Characteristics of HPV infection among 4 084 gynecological outpatients

Feasibility of repeated using 3D printed applicator in brachytherapy for cervical cancer

Related Author

GUAN Tinghong

GONG Chunxia

TU Yuan

TIAN Chenfan

YU Jiaxin

JIANG Peng

SUN Shengjie

YAO Lidi

Related Institution

Department of Gynecology and Obstetrics， the First Affiliated Hospital of Chongqing Medical University

Department of Gynecology and Obstetrics， Women and Children’s Hospital Affiliated to Chongqing Medical University

Department of Radiology， Huzhou Central Hospital

Cancer Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University

⁰