Diagnostic value of serum APE1 autoantibodies in colorectal cancer

何乐; 杨宇馨; 张诗珩; 罗佳; 戴楠; 李梦侠; 单锦露; 王宏毅; 王东

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Diagnostic value of serum APE1 autoantibodies in colorectal cancer

更新时间：2026-01-09

- Diagnostic value of serum APE1 autoantibodies in colorectal cancer
- Journal of Army Medical University Vol. 38, Issue 11, Pages: 1297-1301(2016)
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  CLC： R392.11;R730.43;R735.3
- Published：2016
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何乐,杨宇馨,张诗珩,罗佳,戴楠,李梦侠,单锦露,王宏毅,王东.血清APE1自身抗体在结直肠癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(11):1297-1301.

　He Le,Yang Yuxin,Zhang Shiheng,Luo Jia,Dai Nan,Li Mengxia,Shan Jinlu,Wang Hongyi,Wang Dong.Diagnostic value of serum APE1 autoantibodies in colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(11):1297-1301.
何乐,杨宇馨,张诗珩,罗佳,戴楠,李梦侠,单锦露,王宏毅,王东.血清APE1自身抗体在结直肠癌诊断中的价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(11):1297-1301. DOI：

　He Le,Yang Yuxin,Zhang Shiheng,Luo Jia,Dai Nan,Li Mengxia,Shan Jinlu,Wang Hongyi,Wang Dong.Diagnostic value of serum APE1 autoantibodies in colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(11):1297-1301. DOI：

摘要

目的探讨血清中APE1自身抗体（apurinic/apyrimidinic endonuclease 1 autoantibodies，APE1-AAbs）在结直肠癌中的诊断价值。方法利用ELISA检测150例结直肠癌患者和170例健康体检人员（对照组）血清APE1-AAbs水平，采用蛋白芯片法检测相应的CEA、CA199和CA242浓度。运用Logistic回归和ROC曲线分析方法，将APE1-AAbs与CEA、CA199及CA242联合分析。结果 150例结直肠患者血清APE1-AAbs中位水平为2.697，显著高于对照组（P0.001）。绘制ROC曲线，其AUC为0.797，灵敏度为62.67%，特异性为85.29%。APE1-AAbs分别与CEA、CA199及CA242联合后，AUC、诊断灵敏度和准确性均有所升高。结论血清APE1-AAbs对结直肠癌有辅助诊断价值，与临床上常用的结直肠癌肿瘤标志物联用可提高结直肠癌的诊出率。

Abstract

Objective To explore the diagnostic value of serum apurinic/apyrimidinic endonuclease 1 autoantibodies (APE1-AAbs) in screening colorectal cancer. Methods Serum APE1-AAbs of 150 patients with colorectal cancer and 170 healthy controls were detected by ELISA. Carcinoembryonic antigen (CEA)

carbohydrate antigen 19-9 (CA199) and carbohydrate antigen 242 (CA242) were detected by protein chip technology. Logistic regression and receiver operative characteristic (ROC) curve were employed for combined analysis of APE1-AAbs with CEA

CA199 or CA242. Results The median level of serum APE1-AAbs in the patients with colorectal cancer was 2.697

which was higher than that of the healthy controls (P0.001). With the ROC curve

area under curve (AUC) was 0.797

and the sensitivity and specificity were 62.67% and 85.29%

respectively. The AUC

diagnosis sensitivity and accuracy of colorectal cancer were increased when combining serum APE1-AAbs with CEA

CA199 or CA242. Conclusion Serum APE1-AAbs can help to diagnose colorectal cancer

and its combination with CEA

CA199 or CA242 can improve the early diagnosis accuracy of colorectal cancer.

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