Correlation between cerebral white matter damage and motor function in stroke patients

李鹏岳; 张静娜; 杨君; 颜如冰; 王莉; 张晔; 邱明国

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Correlation between cerebral white matter damage and motor function in stroke patients

更新时间：2026-01-09

- Correlation between cerebral white matter damage and motor function in stroke patients
- Journal of Army Medical University Vol. 38, Issue 10, Pages: 1116-1120(2016)
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  CLC： R445;R743.3;R745.102
- Published：2016
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李鹏岳,张静娜,杨君,颜如冰,王莉,张晔,邱明国.卒中患者脑白质损伤与运动功能的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2016,38(10):1116-1120.

　Li Pengyue,Zhang Jingna,Yang Jun,Yan Rubing,Wang Li,Zhang Ye,Qiu Mingguo.Correlation between cerebral white matter damage and motor function in stroke patients[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(10):1116-1120.
李鹏岳,张静娜,杨君,颜如冰,王莉,张晔,邱明国.卒中患者脑白质损伤与运动功能的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2016,38(10):1116-1120. DOI：

　Li Pengyue,Zhang Jingna,Yang Jun,Yan Rubing,Wang Li,Zhang Ye,Qiu Mingguo.Correlation between cerebral white matter damage and motor function in stroke patients[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(10):1116-1120. DOI：

摘要

目的研究卒中偏瘫患者脑白质结构的损伤程度，并探讨脑白质损伤与运动功能障碍的相关性。方法对17例卒中偏瘫患者和21例健康对照进行大脑DTI数据扫描，应用TBSS方法对两组被试的部分各项异性（FA）、轴向弥散系数（λ

）、径向弥散系数（λ

）进行统计分析；通过约翰霍普金斯白质分区图谱提取卒中患者组的感兴趣区域，并与上肢肢体运动功能评分进行相关分析。结果卒中患者在患侧皮质脊髓束、额枕下束、钩束、丘脑前辐射、上纵束、胼胝体额部和双侧胼胝体枕部的FA值显著降低（P0.005）；患侧皮质脊髓束的λ

值也显著降低（P0.05），患侧皮质脊髓束、额枕下束、钩束、丘脑前辐射、胼胝体额部以及双侧上纵束、胼胝体枕部的λ

值显著升高（P0.01）。患侧皮质脊髓束的λ

值与上肢Fugl-Meyer运动功能评分存在显著正相关（P0.05）。结论卒中患者脑白质纤维束的结构完整性有明显损伤，患侧皮质脊髓束的λ

值可以反映卒中患者运动功能障碍的程度。

Abstract

Objective To investigate the damage of cerebral white matter in stroke patients

and explore the correlation between the white matter damage and the motor dysfunction. Methods Seventeen stroke patients and twenty-one healthy controls were recruited to collect the cerebral diffusion tensor imaging (DTI) data. Fractional anisotropy (FA)

axial diffusivity (λ

) and radial diffusivity (λ

) were analyzed for differences between the 2 groups using tract-based spatial statistics (TBSS). The regions of interest (ROI) were defined based on Johns Hopki

ns white matter partition atlas. The correlations between the parameters of ROI and Fugl-Meyer assessment (FMA) scores of the stroke patients were also analyzed. Results Compared with the healthy controls

the FA of white matter fiber bundles was reduced in the ipsilesional corticospinal tract

inferior fronto-occipital fasciculus

uncinate fasciculus

anterior thalamic radiation

superior longitudinal fasciculus

forceps minor and bilateral forceps major of the stroke patients (P0.005). The λ

values of white matter fiber bundles were reduced in the ipsilesional corticospinal tract (P0.05). The λ

values of white matter fiber bundles were increased in the ipsilesional corticospinal tract

inferior fronto-occipital fasciculus

uncinate fasciculus

anterior thalamic radiation

forceps minor

bilateral forceps major and superior longitudinal fasciculus (P0.01). A positive correlation was found between λ

value of ipsilesional corticospinal tract and FMA score of stroke patients (P0.05). Conclusion Abnormal white matter structure is found in the stroke patients

and the value of λ

in the ipsilesional corticospinal tract can reflect the motor dysfunction.

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