Value of serum soluble triggering receptor expressed on myeloid cell-1  in prognosis of patients with severe sepsis

潘定康; 陈怿; 段鹏凯; 安晓庆; 童华生

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Value of serum soluble triggering receptor expressed on myeloid cell-1 in prognosis of patients with severe sepsis

更新时间：2026-01-09

- Value of serum soluble triggering receptor expressed on myeloid cell-1 in prognosis of patients with severe sepsis
- Journal of Army Medical University Vol. 38, Issue 8, Pages: 845-849(2016)
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  CLC： R392.11;R446.11;R631.2
- Published：2016
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潘定康,陈怿,段鹏凯,安晓庆,童华生.血清可溶性髓样细胞触发受体-1对重症脓毒症患者预后判断价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(08):845-849.

　Pan Dingkang,Chen Yi,Duan Pengkai,An Xiaoqing,Tong Huasheng.Value of serum soluble triggering receptor expressed on myeloid cell-1 in prognosis of patients with severe sepsis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(08):845-849.
潘定康,陈怿,段鹏凯,安晓庆,童华生.血清可溶性髓样细胞触发受体-1对重症脓毒症患者预后判断价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(08):845-849. DOI：

　Pan Dingkang,Chen Yi,Duan Pengkai,An Xiaoqing,Tong Huasheng.Value of serum soluble triggering receptor expressed on myeloid cell-1 in prognosis of patients with severe sepsis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(08):845-849. DOI：

摘要

目的研究血清可溶性髓样细胞触发受体-1(sTREM-1)浓度检测对重症脓毒症患者预后的判断价值。方法回顾性分析重症脓毒症患者共83例，根据28 d死亡结局分为存活组（n=63）和死亡组（n=20），比较2组患者在基本情况、入院24 h APACHEⅡ评分最高值、全血C反应蛋白（C-reactive protein

CRP）和乳酸（lactate，Lac）浓度、血清降钙素（procalcitonin

PCT）和sTREM-1浓度等方面的差异，并绘制ROC曲线分析相关指标对疾病的预后判断及诊断价值，多因素Logistic回归分析探讨与疾病死亡相关的危险因素。结果 2组患者基本情况差异无统计学意义（P0.05）。死亡组患者在APACHEⅡ评分最高值和血清sTREM-1浓度上要高于存活组(P0.05)，而在血清PCT、全血CRP和Lac浓度上2组间比较，则差异无统计学意义(P0.05)。ROC曲线分析结果表明，血清sTREM-1浓度对重症脓毒症患者死亡预测的曲线下面积为0.77。多因素Logistic回归分析结果显示，APACHEⅡ评分和血清sTREM-1浓度是重症脓毒症患者死亡的独立高危因素。结论血清sTREM-1浓度有望成为预测重症脓毒症患者预后的可靠指标，也可能是重症脓毒症患者死亡的独立危险因素。

Abstract

Objective To investigate the value of serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) in the prognosis of patients with severe sepsis. Methods Eight-three patients with severe sepsis were involved in the retrospective study. They were divided into survivor group (n=63) and non-survivor group (n=20) according to 28-day mortality. Baseline indexes

APACHEⅡ peak score

serum concentrations of sTREM-1 and procalcitonin (PCT)

and whole blood levels of C-reactive protein (CRP) and lactate (Lac) were recorded within 24 h after admission

and the differences of above indicators were analyzed. The above indicators in the prognosis was tested by receiver operator characteristic (ROC) curve. Multivariate logistic regression analysis was performed to evaluate the risk factors. Results There was no significant differences in the baseline indexes between the 2 groups (P0.05). The serum concentration of sTREM-1 and APACHEⅡ peak score in the survivors were significantly higher than those in the non-survivors (P0.05). But no significant differences were observed in the serum PCT and blood CRP and Lac (P0.05). The area under ROC curve of serum concentration of sTREM-1 was 0.770. Multivariate logistic regression analysis showed that APACHEⅡ score and serum concentration of sTREM-1 were independent risk factors for the prognosis of severe sepsis. Conclusion The serum concentration of sTREM-1 might be a reliable indicator and independent risk factor for the prognosis of patients with severe sepsis.

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