Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia

廖君; 王晓果; 孔佩艳; 张曦; 易海; 朱丽丹; 刘耀; 张诚; 高蕾

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Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia

更新时间：2026-01-09

- Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia
- Journal of Army Medical University Vol. 38, Issue 12, Pages: 1371-1373(2016)
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  CLC： R341;R730.43;R733.71
- Published：2016
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廖君,王晓果,孔佩艳,张曦,易海,朱丽丹,刘耀,张诚,高蕾.血清uPA蛋白水平与急性髓系白血病的预后有关[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1371-1373.

　Liao Jun,Wang Xiaoguo,Kong Peiyan,Zhang Xi,Yi Hai,Zhu Lidan,Liu Yao,Zhang Cheng,Gao Lei.Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1371-1373.
廖君,王晓果,孔佩艳,张曦,易海,朱丽丹,刘耀,张诚,高蕾.血清uPA蛋白水平与急性髓系白血病的预后有关[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1371-1373. DOI：

　Liao Jun,Wang Xiaoguo,Kong Peiyan,Zhang Xi,Yi Hai,Zhu Lidan,Liu Yao,Zhang Cheng,Gao Lei.Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1371-1373. DOI：

摘要

目的探索尿激酶纤溶酶原激活物(urokinase type plasminogen activator

uPA)在急性髓系白血病(acute myeloid leukemia，AML)患者血清中的表达及与预后的关系。方法采用酶联免疫吸附的方法检测45例初始治疗前AML患者及10例健康体检者血清uPA蛋白表达水平，分别对其中25例预后不良组、10例预后良好组、10例预后中等组患者及10例正常对照组血清uPA蛋白表达水平进行统计学分析比较。结果初始治疗前AML患者血清uPA蛋白表达水平明显高于正常对照组，差异具有统计学意义（P0.05）；预后不良组AML患者血清uPA蛋白表达水平明显高于预后良好组及预后中等组，差异具有统计学意义(P0.05)。结论 uPA蛋白的表达与AML患者危险分层密切相关，监测AML患者血清uPA蛋白表达水平有助于早期判断AML患者的预后。

Abstract

Objective To determine the level of urokinase type plasminogen activator(uPA) in the serum of patients with acute myeloid leukemia(AML) and investigate its correlation with the prognosis of the disease. Methods Serum uPA protein level was determined by enzyme linked immunosorbent assay (ELISA) in 45 untreated AML patients (including 25 poor prognosis patients

10 favorable prognosis patients and 10 moderate prognosis patients) and 10 healthy subjects

and the results were compared and analyzed among the groups. Results The serum level of uPA protein was significantly higher in AML patients than healthy subjects(P0.05).A significant increase of serum uPA levels was found in poor prognosis AML patients compared to other control groups(P0.05). Conclusion The serum level of uPA has a close relationship with the risk stratification of AML. Monitoring the serum uPA level is helpful for early prognostic prediction in newly diagnosed AML patients.

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