Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation

王晓果; 陈婷; 刘焕凤; 邓天霞; 刘俊; 张诚; 张曦; 孔佩艳

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Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation

更新时间：2026-01-09

- Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation
- Journal of Army Medical University Vol. 38, Issue 12, Pages: 1362-1365(2016)
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  CLC： R617;R730.53;R733.71
- Published：2016
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王晓果,陈婷,刘焕凤,邓天霞,刘俊,张诚,张曦,孔佩艳.小剂量地西他滨在异基因造血干细胞移植后早期复发及cGVHD治疗中的作用[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1362-1365.

　Wang Xiaoguo,Chen Ting,Liu Huanfeng,Deng Tianxia,Liu Jun,Zhang Cheng,Zhang Xi,Kong Peiyan.Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1362-1365.
王晓果,陈婷,刘焕凤,邓天霞,刘俊,张诚,张曦,孔佩艳.小剂量地西他滨在异基因造血干细胞移植后早期复发及cGVHD治疗中的作用[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1362-1365. DOI：

　Wang Xiaoguo,Chen Ting,Liu Huanfeng,Deng Tianxia,Liu Jun,Zhang Cheng,Zhang Xi,Kong Peiyan.Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1362-1365. DOI：

摘要

目的分析小剂量地西他滨(decitabine/dacogen，DAC)治疗异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation，allo-HSCT)后慢性移植物抗宿主病（chronic graft versus host disease，cGVHD）患者的转归情况。方法收集2013年6月25日至2015年7月7日我院行allo-HSCT术后早期复发及发生cGVHD，并接受小剂量DAC治疗的4例患者，包括急性髓系白血病(acute myeloid leukemia，AML)3例，骨髓增生异常综合征（myelodysplastic syndrome，MDS)1例。对其诊断、移植方式、cGVHD分型及评分、以及DAC治疗后转归进行分析。结果 4例接受小剂量DAC的患者，cGVHD症状减轻，无严重的血液学毒性。1例因严重肺部感染放弃治疗，3例目前病情稳定。结论小剂量DAC可减轻allo-HSCT术后cGVHD症状，改善患者生存质量，并对早期复发的控制有一定的效果。

Abstract

Objective To analyze the outcomes of 4 cases of chronic graft versus host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) treated by small-dose decitabine/dacogen (DAC). Methods Clinical data of 4 patients who have cGVHD effects and early recurrence after allo-HSCT

and then received small-dose DAC treatment in our hospital from June 25

2013 to July 7

2015 were collected in this study. Three of them were acute myeloid leukemia (AML)

and the other 1 case was myelodysplastic syndrome (MDS).Their diagnosis

transplantation methods

types and scores of cGVHD

and treatment outcome were retrospectively analyzed. Results All 4 patients had decreased effects of cGVHD and had no severe hematologic toxicity after small-dose DCA therapy.One of the patients gave up the treatment because of pulmonary infection

and the other 3 ones were in stable disease stage till now. Conclusion Small-dose DAC therapy alleviates cGVHD after allo-HSCT

improves quality of life in the patients

and has certain effect on controlling early recurrence.

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