Research progress of haploidentical hematopoietic transplantation without T-cell depletion

张曦; 高蕾

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Research progress of haploidentical hematopoietic transplantation without T-cell depletion

更新时间：2026-01-09

- Research progress of haploidentical hematopoietic transplantation without T-cell depletion
- Journal of Army Medical University Vol. 38, Issue 12, Pages: 1331-1339(2016)
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  CLC： R617;R733.7
- Published：2016
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张曦,高蕾.未去除T细胞的单倍型相合造血干细胞移植的研究进展[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1331-1339.

　Zhang Xi,Gao Lei.Research progress of haploidentical hematopoietic transplantation without T-cell depletion[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1331-1339.
张曦,高蕾.未去除T细胞的单倍型相合造血干细胞移植的研究进展[J].陆军军医大学学报(原第三军医大学学报),2016,38(12):1331-1339. DOI：

　Zhang Xi,Gao Lei.Research progress of haploidentical hematopoietic transplantation without T-cell depletion[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(12):1331-1339. DOI：

摘要

Abstract

Human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell transplantation (HLA-haplo HSCT) without T-cell depletion has tremendously progressed over the past 20 years. Advances in graft manipulation

conditioning regimens

and pharmacological graft-versus-host disease (GVHD) prophylaxis have reduced the risk of fatal graft failure and severe GVHD. Donor-specific anti-HLA antibodies (DSA) negative status and killer immunoglobulin-like receptor (KIR) mismatch play potential roles in reducing the risk of graft failure and GVHD following HLA-haplo HSCT. New strategies to improve HLA-haplo HSCT outcomes include donor lymphocyte

selected T-cell subset and NK cell infusion

mesenchymal stem cell (MSC) co-transplantation and interleukin-2 application. Future challenges remain in improving post-transplant immune reconstitution and finding the best approach to reduce the incidence and severity of GVHD while simultaneously preserving the graft-versus leukemia effect to prevent the recurrence of underlying malignancy.

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