Objective      To explore the correlation of fibroblast growth factor 23 (FGF23) genetic polymorphism and coronary heart disease (CHD) in Chongqing Han population.       Methods      A total of 431 subjects were selected from the Department of Cardiology

from May 2014 to March 2015

and were divided into CHD group (n=231) and control group (n=200). All the subjects were unrelated Han populations

and were examined by coronary angiography. Sequenom Massarray system was used for genotyping 3 Tag single-nucleotide polymorphisms (TagSNPs) of FGF23 gene

namely

rs7955866

rs13312756

and rs3812822. The frequencies of alleles

genotypes

and haplotypes of the TagSNPs were compared between the CHD group and the control group.       Results      The frequencies of rs7955866 A allele and rs3812822 C allele in the CHD group were significantly higher than those in the control group (P0.001)

and the genotype distribution of the 2 loci was significantly different between the 2 groups (P0.01). Univariate logistic regression analysis showed that the risk of CHD in the subjects carrying rs7955866 GA genotype was 2.146 folds that of the ones carrying GG genotype (P=0.01

OR=2.146

95%CI: 1.393~3.306)

and the subjects with rs3812822 CT genotype had higher CHD risk than the ones with TT genotype (P= 0.01

OR=2.010

95%CI: 1.327~3.046). After adjusting the confounding factors like gender

age

BMI

smoking history

drinking history

history of hypertension and hypercholesterolemia

the results showed that SNPs at rs7955866 (P0.001

OR=2.478

95%CI: 1.613~3.806) and rs3812822 (P0.001

OR=2.123

95%CI: 1.439~3.132) were independently associated with CHD incidence. The ACC haplotype of rs7955866-rs13312756-rs3812822 had an effect of increasing CHD risk (P0.001; OR=2.074

95%CI: 1.391~3.091).       Conclusion      FGF23 genetic polymorphism is related to the risk of CHD in Chongqing Han population.