Expression of E-cadherin and CD44v6 in human obstructive colorectal cancer: correlation with prognosis

赵鹏; 白鍊; 李启刚; 温泽霖; 简斌; 李中福; 吴帅; 谢建; 廖娟; 钟正福

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Expression of E-cadherin and CD44v6 in human obstructive colorectal cancer: correlation with prognosis

更新时间：2026-01-09

- Expression of E-cadherin and CD44v6 in human obstructive colorectal cancer: correlation with prognosis
- Journal of Army Medical University Vol. 38, Issue 6, Pages: 629-633(2016)
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  CLC： R446.8;R730.23;R735.35
- Published：2016
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赵鹏,白鍊,李启刚,温泽霖,简斌,李中福,吴帅,谢建,廖娟,钟正福.梗阻性结直肠癌中E-cadherin、CD44v6的表达及与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2016,38(06):629-633.

　Zhao Peng,Bai Lian,Li Qigang,Wen Zelin,Jian Bin,Li Zhongfu,Wu Shuai,Xie Jian,Liao Juan,Zhong Zhengfu.Expression of E-cadherin and CD44v6 in human obstructive colorectal cancer: correlation with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(06):629-633.
赵鹏,白鍊,李启刚,温泽霖,简斌,李中福,吴帅,谢建,廖娟,钟正福.梗阻性结直肠癌中E-cadherin、CD44v6的表达及与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2016,38(06):629-633. DOI：

　Zhao Peng,Bai Lian,Li Qigang,Wen Zelin,Jian Bin,Li Zhongfu,Wu Shuai,Xie Jian,Liao Juan,Zhong Zhengfu.Expression of E-cadherin and CD44v6 in human obstructive colorectal cancer: correlation with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(06):629-633. DOI：

摘要

目的探讨梗阻性结直肠癌中E-cadherin（E-cad）、CD44v6的表达及与预后的关系。方法采用免疫组织化学方法分别检测48例梗阻性结直肠癌、121例非梗阻性结直肠癌组织和30例癌旁肠黏膜组织中E-cad和CD44v6蛋白的表达，Kaplan-Meier法绘制生存曲线，Cox比例风险模型多因素分析。结果梗阻性结直肠癌组织中E-cad和CD44v6的标准化阳性率分别为30.2%和81.3%，非梗阻性结直肠癌组织中E-cad和CD44v6的标准化阳性率分别为51.8%和58.9%，两组差异有统计学意义（P0.05）。E-cad的表达与肿瘤pTNM分期、淋巴结转移、分化程度、浸润深度有关（P0.05）。CD44v6表达与肿瘤pTNM分期和淋巴结转移有关（P0.05）。单因素生存分析显示：梗阻、E-cad和CD44v6表达是影响预后的危险因素。Cox回归模型显示：E-cad的表达、淋巴结转移、分化程度为影响结直肠癌患者预后的独立危险因素。结论 E-cad表达下降和CD44v6表达升高与梗阻性结直肠癌较差的预后密切相关。

Abstract

Objective To investigate the expression of E-cadherin (E-cad) and CD44v6 in human obstructive colorectal cancer and their relationships with prognosis. Methods Forty-eight cases of obstructive colorectal cancer

121 cases of non-obstructive colorectal cancer

and 30 cases of adjacent non-tumor tissues were selected for immunohistochemical staining of E-cad and CD44v6 proteins. Survival curves were described with Kaplan-Meier analysis. Multivariate analysis was performed with Cox proportional hazard model. Results There were significant differences in the standardized positive rates of E-cad and CD44v6 between obstructive colorectal cancer group and non-obstructive colorectal cancer group (30.2% vs 51.8%

81.3% vs 58.9%

P0.05). The expression of E-cad was correlated to pTNM stage

node involvement

histological grade and depth of invasion (P0.05). The expression of CD44v6 was correlated to pTNM stage and node involvement. Univariate survival analysis showed that obstruction and expression of CD44v6 and E-cad were the risk factors for prognosis. Cox multivariate analysis showed that the expression of E-cad

node involvement and histological grade were the independent risk factors for the prognosis of patients with colorectal cancer. Conclusion Down-regulated expression of E-cad and up-regulated expression of CD44v6 are closely related to poor prognosis of the patients with obstructive colorectal cancer.

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