Dynamic contrast-enhanced MRI in assessment of microvascular permeability of brain glioma: report of 38 cases

刘颖; 赖利; 王新; 陆明

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Dynamic contrast-enhanced MRI in assessment of microvascular permeability of brain glioma: report of 38 cases

更新时间：2026-01-09

- Dynamic contrast-enhanced MRI in assessment of microvascular permeability of brain glioma: report of 38 cases
- Journal of Army Medical University Vol. 37, Issue 23, Pages: 2397-2399(2015)
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  CLC： R322.13;R445.2;R739.41
- Published：2015
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刘颖,赖利,王新,陆明.动态对比增强磁共振成像对脑胶质瘤微血管通透性评价[J].陆军军医大学学报(原第三军医大学学报),2015,37(23):2397-2399.

　Liu Ying,Lai Li,Wang Xin,Lu Ming.Dynamic contrast-enhanced MRI in assessment of microvascular permeability of brain glioma: report of 38 cases[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(23):2397-2399.
刘颖,赖利,王新,陆明.动态对比增强磁共振成像对脑胶质瘤微血管通透性评价[J].陆军军医大学学报(原第三军医大学学报),2015,37(23):2397-2399. DOI：

　Liu Ying,Lai Li,Wang Xin,Lu Ming.Dynamic contrast-enhanced MRI in assessment of microvascular permeability of brain glioma: report of 38 cases[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(23):2397-2399. DOI：

摘要

目的探讨动态对比增强磁共振成像对脑胶质瘤微血管通透性的定量评价价值。方法总共38例病理证实胶质瘤患者使用3.0T 磁共振仪器进行包括动态对比增强的磁共振检查，获得胶质瘤容积转运常数（K

trans

）和血管外细胞外间隙容积比（Ve）的最大值。不同级别胶质瘤的K

trans

值和Ve值的差异；K

trans

值、Ve值和胶质瘤分级之间的相关性进行统计学分析。结果 Ⅱ级胶质瘤K

trans

值（0.028±0.011 min

-1

）与Ve值（0.081±0.044）均低于Ⅲ级（0.105±0.025 min

-1

，0.456±0.079）和Ⅳ级（0.138±0.053 min

-1

，0.512±0.112），差异具有统计学意义（P0.01），而Ⅲ级和Ⅳ级之间差异无统计学意义（P0.05）。K

trans

值、Ve值和胶质瘤分级，K

trans

值和Ve值均呈显著正相关（P0.001）。 结论 动态对比增强磁共振成像可以定量评价脑胶质瘤微血管通透性并可用于胶质瘤术前分级。

Abstract

Objective To evaluate the value of dynamic contrast-enhanced MRI (DCE-MRI) in the quantitative assessment of microvascular permeability of brain glioma. Methods Clinical data of 38 patients with pathologically confirmed brain gliomas admitted in Southwest Hospital in the year of 2014 were collected in this study. They all received 3.0 T MRI scanning including DCE-MRI to obtain the highest value of volume transfer constant (K

trans

) and volume of extravascular extracellular space per unit

volume of tissue (Ve). The differences in Ktrans and Ve between the different grades and the correlations between K

trans

Ve and glioma grade were statistically analyzed. Results The values of K

trans

and Ve were significant lower in grade Ⅱ glioma (0.028±0.011 min

-1

0.081±0.044) than grade Ⅲ (0.105±0.025 min

-1

，0.456±0.079) and grade Ⅳ (0.138±0.053 min

-1

，0.512±0.112)(P0.01)

but there were no differences between grade Ⅲ and grade Ⅳ glioma (P＞0.05). Positive correlation was found in Ktrans and Ve with glioma grade

and between K

trans

and Ve. Conclusion DCE-MRI can be used to quantitatively assess microvascular permeability and to determine pre-operative grading of glioma.

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Related Institution

Department of Radiology， Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Neurosurgery， Army Medical Center of PLA/Daping Hospital of Third Military Medical University， Chongqing, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Digital Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

School of Medicine， Chongqing University

Institute of Pathology

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