Difference of multi-center controlled clinical efficacy in treatment of neonatal respiratory distress syndrome with different initial doses of pulmonary surfactant

廖翎帆; 龚华; 易明; 龙华; 陈文; 周利刚; 钟晓云; 罗茜

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Difference of multi-center controlled clinical efficacy in treatment of neonatal respiratory distress syndrome with different initial doses of pulmonary surfactant

更新时间：2026-01-09

- Difference of multi-center controlled clinical efficacy in treatment of neonatal respiratory distress syndrome with different initial doses of pulmonary surfactant
- Journal of Army Medical University Vol. 38, Issue 4, Pages: 411-415(2016)
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  CLC： R722.563.8;R972.6
- Published：2016
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廖翎帆,龚华,易明,龙华,陈文,周利刚,钟晓云,罗茜.不同起始量肺表面活性物质治疗新生儿呼吸窘迫综合征的多中心临床疗效比较[J].陆军军医大学学报(原第三军医大学学报),2016,38(04):411-415.

　Liao Lingfan,Gong Hua,Yi Ming,Long Hua,Chen Wen,Zhou Ligang,Zhong Xiaoyun,Luo Qian.Difference of multi-center controlled clinical efficacy in treatment of neonatal respiratory distress syndrome with different initial doses of pulmonary surfactant[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(04):411-415.
廖翎帆,龚华,易明,龙华,陈文,周利刚,钟晓云,罗茜.不同起始量肺表面活性物质治疗新生儿呼吸窘迫综合征的多中心临床疗效比较[J].陆军军医大学学报(原第三军医大学学报),2016,38(04):411-415. DOI：

　Liao Lingfan,Gong Hua,Yi Ming,Long Hua,Chen Wen,Zhou Ligang,Zhong Xiaoyun,Luo Qian.Difference of multi-center controlled clinical efficacy in treatment of neonatal respiratory distress syndrome with different initial doses of pulmonary surfactant[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(04):411-415. DOI：

摘要

目的探讨不同起始量的肺表面活性物质（pulmonary surfactant

PS）治疗新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome，NRDS)的疗效及差异。方法采用前瞻性、多中心对照临床研究方法，按多阶段分层随机抽样的方法，收集三家医院新生儿病房收治的143例新生儿呼吸窘迫综合征的患儿，且使用肺表面活性物质(商品名：珂立苏)治疗，采用完全随机设计的方法分成对照组和实验组，分别使用起始剂量为70 mg/kg 和100 mg/kg 的PS进行治疗，检测并记录使用PS前后不同时间血气分析结果、胸片结果、重复使用PS的次数、并发症的发生、机械通气时间、用氧时间及住院天数等指标。结果 ①两组用药后需氧浓度、PaO

、PaCO

、胸片结果均较用药前有好转(P0.05)；② PS

100

组应用PS后12、24、36 h较PS

组对氧的需求更低(P0.05)，PO2及PCO2改善更明显(P0.05)；③ PS

100

组应用PS后24 h，胸片情况较PS

组明显好转(P0.05)；④PS

100

组在机械通气时间、用氧时间方面均低于PS

组(P0.05)。结论应用肺表面活性物质治疗NRDS起始剂量为100 mg/kg 的疗效优于70 mg/kg。

Abstract

Objective To investigate the difference of clinical efficacy in treatment of neonatal respiratory distress syndrome (NRDS) with different initial doses of pulmonary surfactant (PS). Methods Prospective multi-center controlled clinical trials and multi-stage stratified random sampling were employed

and 143 cases of NRDS

treated with PS from 3 NICUs were enrolled in the trails. The neonates were randomly divided into 2 groups

which were treated with initial dose of PS at 70 mg/kg (PS

) and at 100 mg/kg (PS

100

)

respectively. Blood gas analysis

chest X-ray results

repeated use of PS

complication occurrence

duration of mechanical ventilation

oxygen therapy and hospitalization were analyzed. Results The data demonstrated that PaO

PaCO

and chest X-ray results were improved in both groups after PS treatment (P0.05). PS

100

group had lower oxygen demand (P0.05) at 12

24 h and 36 h after PS administration compared with PS

group

and PO

and PCO

were improved more significantly in PS

100

group (P0.05). PS

100

group showed significantly improved chest X-ray results at 24 h after PS administration compared with PS

group (P0.05). Duration of mechanical ventilation and oxygen therapy were reduced more in PS

100

group than in PS

group (P0.05). Conclusion PS exerts better clinical efficacy in NRDS at the initial dose of 100 mg/kg than at 70 mg/kg.

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