Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma

董树岭; 尹惠卿; 吕彦萌; 孟伟伟; 董翠翠; 贺付成

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Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma

更新时间：2026-01-09

- Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma
- Journal of Army Medical University Vol. 38, Issue 1, Pages: 85-88(2016)
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  CLC： R394.2;R730.261;R735.1
- Published：2016
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董树岭,尹惠卿,吕彦萌,孟伟伟,董翠翠,贺付成.miRNA-205在食管鳞状细胞癌患者组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2016,38(01):85-88.

　Dong Shuling,Yin Huiqing,Lyu Yanmeng,Meng Weiwei,Dong Cuicui,He Fucheng.Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(01):85-88.
董树岭,尹惠卿,吕彦萌,孟伟伟,董翠翠,贺付成.miRNA-205在食管鳞状细胞癌患者组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2016,38(01):85-88. DOI：

　Dong Shuling,Yin Huiqing,Lyu Yanmeng,Meng Weiwei,Dong Cuicui,He Fucheng.Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(01):85-88. DOI：

摘要

目的探讨miRNA-205在食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）患者组织中的表达情况。方法收集56例经病理确诊的ESCC患者的手术切除组织（癌组织及其癌旁组织），采用实时荧光定量聚合酶链式反应（real-time quantitative polymerase chain reaction，qRT-PCR）检测miRNA-205的表达，并分析miRNA-205在不同临床病理资料之间的差异。结果 ESCC患者组织中miRNA-205相对表达量为1.475（0.444~5.478），显著高于癌旁组织（Z=－3.067，P=0.002）；miRNA-205在不同TNM分期ESCC患者组织中存在差异，TNM分期越高，miRNA-205表达量越高，差异具有统计学意义（F=36.335

P0.001）；miRNA-205在淋巴结转移阴性/阳性组织中存在差异，淋巴结转移阳性组miRNA-205表达量显著高于淋巴结转移阴性组（Z=－3.353，P=0.001）。结论 miRNA-205在ESCC患者癌组织中表达升高，并可能参与ESCC的发生与发展。

Abstract

Objective To determine the expression profile of miRNA-205 in the patients with esophageal squamous cell carcinoma (ESCC). Methods Matched ESCC and corresponding adjacent non-cancerous tissue samples were obtained from 56 patients who were pathologically diagnosed with ESCC and surgically treated in our hospital from August to December 2014. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression levels of miRNA-205

and the results were analyzed with clinicopathological parameters. Results The expression level of miRNA-205 was 1.475 (0.444~5.478) in ESCC tissues

significantly higher than that in the corresponding adjacent non-cancerous tissues (Z=-3.067

P=0.002). The expression level of miRNA-205 in ESCC tissues was well correlated with TNM stages

with the higher expression level

the higher grade of the TNM stages (F=36.335

P＜0.001). Its expression level was higher in the patients with metastatic lymph node than those without (Z=-3.353，P=0.001). Conclusion The expression level of miRNA-205 is up-regulated in ESCC

and it might be involved in the initiation and progression of ESCC.

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