Objective      To determine the correlation of clinical factors and dose-volume metrics with the risk factors of acute bone marrow suppression during concurrent chemoradither

apy in cervical cancer patients.       Methods      Clinical data of 139 patients receiving concurrent chemoradiotherapy for cervical cancer admitted in our hospital from January 2012 to December 2014 were enrolled in this study. The prognostic clinical factors and dose volume metrics were analyzed with univariate analysis and multivariate analysis (Logistic regression model). Prognostic clinical factors

including age

clinical stage

pathological type

chemotherapy cycles

original hemoglobin levels

methods of radiotherapy

and chemotherapy regimens were evaluated for their association with dose volume metrics (V

5

V

10

V

15

V

20

V

25

V

30

V

35

V

40

V

45

V

50

V

55

D

max

and D

mean

) and acute bone marrow suppression.       Results      About 80.6% (112/139) patients developed ≥2 grade acute bone marrow suppression. Univariate analysis showed that the related factors for ≥2 grade acute bone marrow suppression were the dose irradiation of V

5

V

10

V

15

V

20

V

25

and D

mean

. Multivariate logistic regression analysis showed that V

10

was the independent risk factor for acute bone marrow suppression (P0.05)

and receiver operating characteristic (ROC) curve verified that the pelvis threshold V

10

was 92%.       Conclusion      V

10

is the independent risk factor for bone marrow suppression. V

10

should be controlled below 92% in treatment plan to reduce the occurrence of ≥2 grade acute bone marrow suppression.