Value of PET/CT in design of irradiation target volume in patients with non-small cell lung cancer

邢祥菊; 庞学利

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Value of PET/CT in design of irradiation target volume in patients with non-small cell lung cancer

更新时间：2026-01-09

- Value of PET/CT in design of irradiation target volume in patients with non-small cell lung cancer
- Journal of Army Medical University Vol. 38, Issue 5, Pages: 501-505(2016)
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  CLC： R730.55;R734.2;R814.42
- Published：2016
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邢祥菊,庞学利.PET/CT在非小细胞肺癌放射治疗勾画靶区中的价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(05):501-505.

　Xing Xiangju,Pang Xueli.Value of PET/CT in design of irradiation target volume in patients with non-small cell lung cancer[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(05):501-505.
邢祥菊,庞学利.PET/CT在非小细胞肺癌放射治疗勾画靶区中的价值[J].陆军军医大学学报(原第三军医大学学报),2016,38(05):501-505. DOI：

　Xing Xiangju,Pang Xueli.Value of PET/CT in design of irradiation target volume in patients with non-small cell lung cancer[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(05):501-505. DOI：

摘要

目的采用PET/CT分析非小细胞肺癌（non-small cell lung cancer，NSCLC）纵隔淋巴结转移特点，为放疗患者勾画靶区提供参考依据。方法 375例初治NSCLC患者在治疗前行

F-FDG PET/CT扫描，对不同原发灶部位、分期及病理类型发生纵隔淋巴结转移情况进行统计分析。结果 PET/CT结果显示，207例右肺NSCLC纵隔淋巴结转移率由高到低依次为同侧肺门、4R、7、5、2R、10～11L、6区；168例左肺NSCLC纵隔淋巴结转移率依次为同侧肺门淋巴结、5、7、6、4L、4R、10～11R区。中肺和下肺NSCLC的7区转移率显著高于上肺。鳞癌和腺癌纵隔淋巴结转移差异无统计学意义（P0.05）。随着患者T分期增加，更容易发生纵隔淋巴结转移。375例NSCLC患者中有88例发生了跳跃式转移，占23.5%。191个跳跃转移区中，4R、7、5、6、2R占有较高比例。纵隔淋巴结跳跃式转移与NSCLC原发灶部位、病理类型及分期无相关性（P0.05）。结论 PET/CT提示左右肺NSCLC患者纵隔淋巴结转移高危区不同，建议右肺NSCLC放疗靶区应包括10～11R、4R、7、5区；左肺NSCLC放疗靶区应包括10～11L、5、7、6、4L、4R区。

Abstract

Objective To obtain reference data for designing rational irradiation target volume by the characteristics of mediastinal lymph node metastasis in non-small cell lung cancer (NSCLC) patients by positron emission tomography/computed tomography (PET/CT). Methods The

F-FDG PET/CT data of 375 NSCLC patients freshly diagnosed by pathology in our hospital from 2012 to 2015 before treatment were collected. The distribution characteristics of mediastinal lymph node metastasi

s with different lesion location

clinical stage

and pathologic types were analyzed. Results PET/CT scanning indicated that in the 207 patients with right lung NSCLC

the metastasis incidences of mediastinal lymph nodes were decreased as the following order

ipsilateral hilar nodes

10~11L and 6. And for the 168 patients with left lung NSCLC

the highest metastasis incidence of mediastinal lymph nodes was the ipsilateral hilar nodes

followed by 5

4R and 10~11R. The metastatic rate of zone 7 area was significantly higher in inferior and middle lobe lung than in the superior lobe lung for the patients. There was no significant differences in the mediastinal lymph node metastasis between the squamous carcinoma and adenocarcinoma (P0.05). With the increasing of T stage

the patients were prone to mediastinal lymph node metastasis. There were 88 patients having skip metastasis among the 375 patients

accounting for 23.5%. In the 191 skip metastasis areas

6 and 2R had higher percentages. Mediastinal lymph nodes metastasis had no correlation with location

pathological type and stage in primary lung lesion P0.05). Conclusion PET/CT results indicate that the high risk metastatic areas are different in the right and left NSCLC

and clinical irradiation target volume should include zones 10~11R

7 and 5 for the patients of right lung NSCLC

and 10~11L

4L and 4R.

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