Objective      To investigate the effect of intensive insulin therapy (IIT) on glucose and lipid metabolism

infection rate and prognosis in severe brain injury patients with parenteral nutrition support and evaluate the clinical significance.       Methods      A randomized controlled assessment was designed

and 66 hospitalized severe brain injury patients with parenteral nutrition support from September 2013 to August 2014 were randomly assigned to treatment group and control group by random number table (n=33). The treatment group adopted IIT to maintain glucose levels at 4.4-6.6 mmol/L

and insulin was infused only when blood glucose levels exceeded 11.0 mmol/L in the control group. The outcomes including glucose and lipid metabolism indexes on 0

7 and 14 d after treatment

incidence of nosocomial infection

hospital stays

and Glasgow outcome scale (GOS) scores after 6-month follow-up were compared.       Results      In 0 and 7 d

there was no significant difference in the glucose and lipid metabolism indexes between the 2 groups (P0.05). On the 14 d after treatment

triglyceride concentration was relatively lower and high-density lipoprotein level was relatively higher in the treatment group (P0.05)

but low-density lipoprotein had no significant difference (P0.05). The incidence of nosocomial infection was lower in the treatment group than the control group (P0.05)

and the hospital stays were shorter (P0.05). The GOS scores after 6-month follow-up were similar in the 2 groups (P0.05).       Conclusion      IIT can help the severe brain injury patients with parenteral nutrition support to reduce the incidence of hyperglycemia

hyperlipidemia and infection

and improve the outcomes.