Objective      To investigate the effect of apolipoprotein E mimetic peptide COG1410 on the early cerebral edema

aquaproin-4 (AQP-4) expression and movement function in mice with early brain injury (EBI) after subarachnoid hemorrhage (SAH).       Methods      SAH model was established by endovascular perforation. A total of 108 male C57BL/6J mice were randomly divided into sham group

SAH+saline group and SAH+COG1410 group. The expression of AQP-4 in the brain of mice was measured by RT-PCR

immunohistochemistry and ELISA. The water content of the cerebral tissues was determined by the dry-wet weight method.       Results      After SAH

the nerve function scores of the SAH+saline group and SAH+COG1410 group were significantly higher than those of the sham group (P0.05)

and there was statistically significant difference between the SAH+saline group and the SAH+COG1410 group (P0.05). Compared with the sham group

the brain water content and the AQP-4 protein and mRNA expression levels in the SAH+saline group and SAH+COG1410 group were increased at each time point after SAH (P0.05). The brain water content and the AQP-4 protein and mRNA expression levels in the SAH+saline group and SAH+COG1410 group were significantly increased in 1 d after SAH

reached the peak on 2 d

and then gradually declined (P0.05).       Conclusion      Administration of COG1410 significantly inhibits the cerebral edema via inhibition of AQP-4 expression.