Objective      To determine the effect of rosuvastatin at intensive (20 mg

qd) and regular doses (10 mg

qd) on carotid atherosclerosis in Chinese patients in order to explore a safe and effective dose of rosuvastatin for Chinese population.       Methods      Databases of PubMed

Medline

EMBASE

CNKI

VIP and CBM were searched for randomized controlled trails (RCTs) or semi-randomized controlled trails concerning about the treatment of atherosclerosis by rosuvastatin from the year of 2007 to 2015. The Meta-analysis evaluation software Revman 5.0 was applied to analyzed the obtained studies. The changes of intima-media thickness (IMT)

low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C)

and side effects after different doses of rosuvastatin treatment were compared in different doses.       Results      Meta-analysis showed that 20 mg rosuvastatin showed stronger reduction in IMT (MD＝-0.14

95%CI: -0.21

-0.07)

significant decrease in LDL-C level (MD＝-0.53

95%CI:-0.75

-0.30)

and obvious elevation in HDL-C level (MD＝0.13

95%CI: 0.09

0.17) when compared with 10 mg rosuvastatin （all P0.000 01）. There was no significant difference in the incidence of side effects between the 2 doses.       Conclusion      Rosuvastatin of 20 mg is superior to 10 mg dose in reduce of LDL-C

increase of HDL-C

and decrease of IMT

and the 2 doses are of  comparative similar safety.