Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis

郑江; 郑新川

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Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis

更新时间：2026-01-09

- Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis
- Journal of Army Medical University Vol. 38, Issue 4, Pages: 323-329(2016)
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  CLC： R631
- Published：2016
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郑江,郑新川.以细菌主要病原体相关分子为靶标的脓毒症防治策略[J].陆军军医大学学报(原第三军医大学学报),2016,38(04):323-329.

　Zheng Jiang,Zheng Xinchuan.Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(04):323-329.
郑江,郑新川.以细菌主要病原体相关分子为靶标的脓毒症防治策略[J].陆军军医大学学报(原第三军医大学学报),2016,38(04):323-329. DOI：

　Zheng Jiang,Zheng Xinchuan.Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(04):323-329. DOI：

摘要

Abstract

Sepsis is a life-threatening disease for infected patients and there are few effective remedies for sepsis. Almost all the therapeutic strategies based on anti-inflammation or anti-coagulation have been failed since sepsis is a complicated inflammatory response that involves immune

coagulation and neuroendocrine systems

and thus the treatments directed against only one of the systems are not able to produce beneficial effects.Pattern recognition theory which means the pathogen-associated molecular patterns trigger sepsis by being recognized by pattern recognition receptors

elucidates the mechanism of sepsis

therefore we present a strategy on the management of sepsis at the source by targeting the major bacterial pathogen-associated molecular patterns. According to the current studies

the strategy is feasible thus providing a promising way to treat sepsis.

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Related Author

郑江

郑新川

DU Zhongyuan

LIU Yiyan

BAO Daiqin

ZHAO Yibo

GUO Juncai

LI Yuxuan

Related Institution

Medical Research Center, Southwest Hospital, Third Military Medical University

The First School of Clinical Medicine， Nanjing Medical University

School of Basic Medical Sciences， Southwest Medical University

School of Pharmacy and Bioengineering， Chongqing University of Technology

National Key Laboratory of Trauma and Chemical Poisoning，Department of War Trauma， Shock and Blood Transfusion，Daping Hospital， Army Medical University

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