Objective      To evaluate the therapeutic effect of one-stage anterior iliac crest allografting and instrumentation on the patients with spinal tuberculosis after radical debridement and decompression and assess the safety and efficacy.       Methods      Sixty patients

admitted in our department from Jan 2008 to Dec 2012

were diagnosed with spinal tuberculosis

and their clinical data were analyzed retrospectively. These patients were treated with proper anterior or lateral anterior bone allografting and internal fixation after radical debridement and decompression. The follow-up period ranged from 9 to 36 months (mean 22.80±7.71 months). All the patients received chemotherapy for 12-18 months and had brace immobilization for 3-6 months after operation. The general clinical data including liver function

renal function

high-sensitivity C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were collected regularly. Changes in deformity correction and bony fusion were assessed by comparing preoperative

postoperative and latest imaging data obtained by X-ray imaging

computed tomography and magnetic resonance imaging.       Results      No neurological major vascular injuries or other complications were observed. According to Bridwell criteria

56 cases had grade Ⅰ fusion and 5 cases had grade Ⅱ fusion in 9-12 months. The average kyphotic correction loss was 2.38°±1.86°.       Conclusion      Based on standard chemotherapy

the lesion is completely eliminated. The kyphosis is effectively corrected and spinal stability is reconstructed through one-stage anterior iliac crest allografting and instrumentation. This suggests that bone allograft is a suitable bone graft material for clinical surgery.