Objective      To research the resting-state neutral networks in the newly diagnosed juvenile myoclonic epilepsy (JME) by functional magnetic resonance imaging (fMRI) and explore the pathophysiological mechanism of cognitive impairment.       Methods      Twenty-three JME patients and twenty-three healthy controls were recruited

and the whole brain data were collected by resting-state fMRI. Fractional amplitude of low frequency fluctuation (fALFF) was used to analyze the resting-state brain activity in the JME patients and healthy controls

and the brain functi

on networks were constructed to analyze abnormal brain networks in the JME patients. The whole brain 3D T

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WI images of the JME patients and healthy controls were also collected

and the cortex thickness difference between the JME patients and healthy controls was observed with curved surface-based cortex morphology method.       Results      Compared with the healthy controls

the JME patients had lower fALFF values at the left medial superior frontal gyrus and right inferior parietal lobule

and higher fALFF values at the right fusiform

left precentral gyrus

and left postcentral gyrus. The higher regional homogeneity (ReHo) values were distributed at the left inferior temporal gyrus and right precentral gyrus

while the lower ReHo values were distributed at the left anterior cingulate cortex and left frontal central. The left orbital frontal Hub region disappeared. The cortical thickness of the right angular gyrus

right middle temporal gyrus and right inferior temporal gyrus was decreased. The differences were statistically significant (P0.01).       Conclusion      The frontotemporal thalamocortical network appears in the newly diagnosed JME patients in the resting state

and this pathological neural network suppresses or even destroys the function of normal physiological neural networks

leading to cognitive impairment in memory

attention and execution.