Objective       To systemically review the correlation of obstructive sleep apnea syndrome (OSAS)and primary open angle glaucoma (POAG).       Methods      Literatures concerning the correlation between OSAS and glaucoma were searched in PubMed

EMbase

Web of Science

WanFang Data and CNKI (from the date of the databases founded to November 2014). Two researchers did systematic analysis to the data with RevMan5.3 software provided by the Cochrane Collaboration throughout screening the literatures independently according to the inclusive criteria

extracting the data

assessing the quality and cross checking.       Results      Four case-control studies and 2 cohort studies were included in this article

totally 19 226 participants. The results showed that OSAS was related with glaucoma (OR=2.03

95％CI=1.68~2.45

P0.01). In subgroups according to the race and nation analysis

the correlation between OSAS and glaucoma was determined for the Turk (OR=8.42

95％CI=1.05~67.41

P=0.04) and Taiwannese (OR=1.99

95％CI=1.64~2.40

P0.01)

but not for the British (OR=0.87

95％CI=0.09~8.76

P=0.91). In the subgroups according to the severity of OSAS

the correlation was certain in the patients with severe OSAS (OR=11.30

95％CI=1.40~91.37

P=0.02)

but not in those with mild (OR=3.13

95％CI=0.32~30.89

P=0.33) and with moderate OSAS (OR=5.16

95%CI=0.56~47.21

P=0.15).       Conclusion      OSAS might be a risk factor for POAG.