Influence of non-fasting and fasting treatments on water-immersion and restraint stress-induced gastric mucosal injury in rats

桂红珍; 杨浪; 盛剑秋; 乔宝军

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Influence of non-fasting and fasting treatments on water-immersion and restraint stress-induced gastric mucosal injury in rats

更新时间：2026-01-09

- Influence of non-fasting and fasting treatments on water-immersion and restraint stress-induced gastric mucosal injury in rats
- Journal of Army Medical University Vol. 37, Issue 20, Pages: 2053-2056(2015)
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  CLC： R-332;R459.3;R573.1
- Published：2015
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桂红珍,杨浪,盛剑秋,乔宝军.非禁食对浸水-束缚应激大鼠胃黏膜损伤的保护作用[J].陆军军医大学学报(原第三军医大学学报),2015,37(20):2053-2056.

　Gui Hongzhen,Yang Lang,Sheng Jianqiu,Qiao Baojun.Influence of non-fasting and fasting treatments on water-immersion and restraint stress-induced gastric mucosal injury in rats[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(20):2053-2056.
桂红珍,杨浪,盛剑秋,乔宝军.非禁食对浸水-束缚应激大鼠胃黏膜损伤的保护作用[J].陆军军医大学学报(原第三军医大学学报),2015,37(20):2053-2056. DOI：

　Gui Hongzhen,Yang Lang,Sheng Jianqiu,Qiao Baojun.Influence of non-fasting and fasting treatments on water-immersion and restraint stress-induced gastric mucosal injury in rats[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(20):2053-2056. DOI：

摘要

目的探讨非禁食和禁食对大鼠应激性胃溃疡胃黏膜损伤及MMP-9、TIMP-2表达的影响。方法非禁食应激组不予禁食，禁食应激组于应激前24 h禁食。用浸水-束缚应激(water-immersion and restraint stress，WIRS)建立大鼠应激性溃疡模型。应激3 h后，观察非禁食应激组和禁食应激组大鼠胃黏膜病变，对溃疡指数(UI)进行评分；组织学观察胃出血；用Western blot检测胃黏膜MMP-9、TIMP-2的蛋白表达。结果 WIRS应激3 h能成功诱导大鼠应激性胃溃疡。非禁食应激组与禁食应激组比较，应激性胃溃疡大鼠的UI后者高于前者（P0.01)，黏膜层炎性细胞浸润数后者高于前者（P0.01)，WIRS大鼠胃黏膜MMP-9蛋白表达后者显著高于前者（P0.01)，而TIMP-2蛋白表达后者略低于前者（P0.05）。结论非禁食应激可显著减少MMP-9表达。非禁食处理减轻浸水-束缚应激大鼠胃黏膜损伤。

Abstract

Objective To investigative the influence of non-fasting and fasting treatments on water-immersion and restraint stress (WIRS)-induced gastric mucosal injury and on the expression of MMP-9 and TIMP-2 in rats. Methods The non-fasting group was not fasting

and the fasting group was fasting at 24 h before WIRS. Stress-induced ulcer model was established by WIRS. The gastric mucosa was examined and the ulcer index (UI) was evaluated after 3-hour WIRS. Mucosal injury was observed with histological method. In addition

the protein expressions of MMP-9 and TIMP-2 were measured by Western blotting. Results The rat ulcer model was established by 3-hour WIRS. The UI

inflammatory cells and MMP-9 protein expression in the mucosa were higher in the fasting group than in the non-fasting group (P0.01)

while the TIMP-2 protein expression was slightly lower in the fasting group (P0.05). Conclusion Non-fasting treatment can alleviate WIRS-induced gastric mucosal injury through significantly down-regulating the expression of MMP-9 in the rats.

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