Objective      To observe the clinical characteristics of high-risk prethreshold and threshold retinopathy of prematurity (ROP).        Methods      There were 106 premature infants diagnosed with high-risk prethreshold or threshold ROP in our hospital from January 2011 to December 2012. The clinical characteristics such as gestational ages

birth weights

disease stages and disease zones were summarized.       Results      The gestational ages of the ROP infants were 28.70±1.89 weeks

and there were 44.34% infants ≤28 weeks

2 infants 24 weeks

2 infants 25 weeks

and 84.91% infants ≤30 weeks. The diseased infants had birth weights of 1 190.00±282.33 g

and included 86.27% infants less than 1 500 g

20.59% infants less than 1 000 g

and 3 infants more than 2 000 g. There were 2.83% infants in stage Ⅰ

21.70% in stage Ⅱ

73.58% in stage Ⅲ

1.89% in stage Ⅳ

and zero in stage V. Among the ROP infants

33.96% diseased in zone Ⅰ and 66.04% diseased in zone Ⅱ. The gestational ages and birth weights of the infants with ROP in zone I were 28.94±1.57 weeks and 1 224.31±196.04 g

respectively

while those of the infants with ROP in zone Ⅱ were 28.51±2.03 weeks and 1 168.54±321.32 g

respectively

and there was no significant difference (P0.05). The correct gestational ages suitable for treating ROP in zone Ⅰ and ROP in zone Ⅱ were 35.09±1.28 weeks and 38.43±6.32 weeks

respectively

and there was significant difference (P=0.000).       Conclusion      In China

there are still more larger and more mature infants progressed to high-risk prethreshold and threshold ROP

and the present guidelines are suitable for our country’s conditions. The infants with ROP in zone I were always earlier progressed to high-risk prethreshold and threshold ROP

so early screening and frequent screening should be done to support timely treatment.