Expression and clinical significance of 3β-hydor-xysteroid-△24 reducase in colorectal cancer

王灿灿; 王喆; 秦虹; 彭媛; 张月; 梁后杰; 阮志华

您当前的位置：

首页 >

文章列表页 >

Expression and clinical significance of 3β-hydor-xysteroid-△24 reducase in colorectal cancer

更新时间：2026-01-09

- Expression and clinical significance of 3β-hydor-xysteroid-△24 reducase in colorectal cancer
- Journal of Army Medical University Vol. 37, Issue 11, Pages: 1161-1165(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R345;R730.43;R735.35
- Published：2015
- 稿件说明：
移动端阅览
王灿灿,王喆,秦虹,彭媛,张月,梁后杰,阮志华.24-脱氢胆固醇还原酶在结直肠癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2015,37(11):1161-1165.

　Wang Cancan,Wang Zhe,Qin Hong,Peng Yuan,Zhang Yue,Liang Houjie,Ruan Zhihua.Expression and clinical significance of 3β-hydor-xysteroid-△24 reducase in colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(11):1161-1165.
王灿灿,王喆,秦虹,彭媛,张月,梁后杰,阮志华.24-脱氢胆固醇还原酶在结直肠癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2015,37(11):1161-1165. DOI：

　Wang Cancan,Wang Zhe,Qin Hong,Peng Yuan,Zhang Yue,Liang Houjie,Ruan Zhihua.Expression and clinical significance of 3β-hydor-xysteroid-△24 reducase in colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(11):1161-1165. DOI：

摘要

目的检测24-脱氢胆固醇还原酶（3β-hydor-xysteroid-△24 reducase，DHCR24）在结直肠癌及癌旁肠黏膜中的表达，探讨其临床意义。方法应用组织芯片技术结合免疫组化法检测第三军医大学3所附属医院结直肠癌术后125例组织标本以及相应63例癌旁肠黏膜中DHCR24的表达。结果 DHCR24在125例结直肠癌组织中阳性表达率显著高于癌旁肠黏膜（67.2% vs 39.7%，P0.01），并与肿瘤的分化程度、临床分期、淋巴结转移等有关（P0.05），结直肠癌患者中DHCR24高表达组比低表达组预后差（P0.01），临床分期高的结直肠癌患者中，DHCR24的高表达提示了临床预后差 (P0.01)，但在临床分期低的患者中不存在这种差异(P0.05)。结论 DHCR24在结直肠癌组织中高表达，且结直肠癌患者中DHCR24高表达组比低表达组预后差，提示其在结直肠癌的发生、发展中可能发挥着重要作用。

Abstract

Objective To determine the expression level of 3β-hydor-xysteroid-△24 reducase (DHCR24) in colorectal cancer and adjacent mucosa tissues

and explore its clinical significance. Methods Tissue microarray and immunohistochemical staining was applied for the detection of DHCR24 expression in 125 cases of colorectal cancer and 63 adjacent mucosa tissues through surgical treatment. The results were analyzed with the clinical data. Results The positive expression rate of DHCR24 was significantly higher in the colorectal cancer tissue than in the adjacent mucosa tissue (67.2% vs 39.7%

P0.01). DHCR24 expression was significantly correlated with tumor differentiation degree

clinical stage and lymph node metastasis (P0.05). The patients with high expression of DHCR24 had poorer prognosis (P0.01). Among the patients who had advanced-stage colorectal cancer

higher DHCR24 expression suggested a poorer survival (P0.01). But no such suggestion was seen in the patients at early stage disease (P0.05). Conclusion DHCR24 is highly expressed in colorectal cancer tissue

and the patients with high expression predicts poorer prognosis. DHCR24 might play an important role in the malignant progression of colorectal cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of 6-phosphofructokinase-2 in colorectal cancer and its clinical significance

Expression of fatty acid amide hydrolase in colorectal cancer and its clinical significance

MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer

Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer

Preparation of nanosized hypoxia-inducible factor 1α inhibitor and its application in reversing chemoresistance in colorectal cancer cells

Related Author

魏莱

王喆

梁后杰

邓佳

谢赣丰

舒秋霞

王宁

ZHANG Min

Related Institution

School of Medicine, Xinyang Hospital of Traditional Chinese Medicine

School of Pharmaceutical Sciences， Xinyang Vocational and Technical College， Xinyang， Henan, Xinyang Hospital of Traditional Chinese Medicine

Department of Pathology, Xinyang Hospital of Traditional Chinese Medicine

Department of Oncology, Renmin Hospital of Wuhan University

Department of Pharmacy, Renmin Hospital of Wuhan University

⁰