Objective       To summarize our experiences of autologous microskin grafting in treatment of extensive deep partial and full thickness burn wounds.       Methods       Autologous microskin grafting was performed in 214 patients with severe burns during the period of November 2002 to August 2013 in our hospital. Their clinical data

including demographic information

clinical outcomes

wound healing indexes as well as the degree of scar hyperplasia

were all collected and categorized. The factors affecting the prognosis

wound healing and short- and long-term healing were analyzed.       Results       The mortality of the patients underwent aggressive eschar excision and autologous microskin grafting was 16.1% and 32.1% respectively within and after 7 d postburn (P0.05). In terms of expansion ratio between recipient-site to donor-site surface area for a total of 377 skin grafting sites

the ratio ranging from 5∶1 to 10∶1 had a higher primary wound healing rate [(77.23±19.91)%] than the ratio of less than 5∶1

and a better wound healing speed than that of more than 10∶1 [(1.84±0.76)%/d vs (1.53±0.51)%/d

P0.05]. Among 307 skin grafting regions

repeated ulceration of newly formed epidermis accounted for 56.68% (174/307) of all the grafted positions after short term. The higher primary wound healing rates was closely related to less scar hyperplasia in 189 skin grafting regions (Chi square=11.697

P0.05).       Conclusion       The aggressive eschar excision and autologous microskin grafting within 7 d postburn significantly reduces the mortality of patients with extensive deep burns wounds. The ratio ranging from 5∶1 to 10∶1 has a good wound healing efficacy. The improvement of primary wound healing rate promotes the long-term prognosis of the patients.