Objective      To explore whether propofol can replace sodium pentobarbital in Wada test to determine the language and memory advantage hemispheres.      Methods      Forty-two cases of Wada test with propofol as sodium pentobarbital substitute during February 2012 to April 2014 were retrospectively analyzed. The successful rate and safety were summarized

and the determination effectiveness of language and memory advantage hemispheres was analyzed.      Results      In Wada test

unilateral dosage of propofol was 7-24 mg (13.8±3.6 in average). Among 42 cases of Wada test

38 cases were completed smoothly

and the successful rate was 90.5%. In the 38 cases

11 sides of 76 sides of test patients showed different degrees of adverse reactions

and the incidence of adverse reactions was 14.5%. Of the completed 38 cases

37 cases determined the language advantage hemisphere

with the effective rate of 97.4%

and 27 cases determined the memory advantage hemisphere

with the effective rate of 71.1%. Tverb and Tnerb had statistically significant difference between left side and right side

between the language advantage hemisphere and non-advantage hemisphere

and between the memory advantage hemisphere and non-advantage hemisphere (P0.05).      Conclusion      Application of propofol in Wada test is relatively safe and effective

so it can replace sodium pentobarbital to determine the language and memory advantage hemispheres.