Efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents in treatment of coronary heart disease patients with diabetes

罗远林; 王玉清; 王芳娟; 黄岚; 赵晓辉

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Efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents in treatment of coronary heart disease patients with diabetes

更新时间：2026-01-09

- Efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents in treatment of coronary heart disease patients with diabetes
- Journal of Army Medical University Vol. 37, Issue 9, Pages: 912-915(2015)
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  CLC： R197.39;R541.405;R587.1
- Published：2015
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罗远林,王玉清,王芳娟,黄岚,赵晓辉.可降解涂层与永久性涂层药物洗脱支架治疗冠心病合并糖尿病患者的有效性及安全性研究[J].陆军军医大学学报(原第三军医大学学报),2015,37(09):912-915.

　Luo Yuanlin,Wang Yuqing,Wang Fangjuan,Huang Lan,Zhao Xiaohui.Efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents in treatment of coronary heart disease patients with diabetes[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(09):912-915.
罗远林,王玉清,王芳娟,黄岚,赵晓辉.可降解涂层与永久性涂层药物洗脱支架治疗冠心病合并糖尿病患者的有效性及安全性研究[J].陆军军医大学学报(原第三军医大学学报),2015,37(09):912-915. DOI：

　Luo Yuanlin,Wang Yuqing,Wang Fangjuan,Huang Lan,Zhao Xiaohui.Efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents in treatment of coronary heart disease patients with diabetes[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(09):912-915. DOI：

摘要

目的比较可降解涂层与永久性涂层药物洗脱支架治疗冠心病合并糖尿病患者的远期疗效及安全性。方法回顾性分析2008年1月至2012年12月我院确诊为冠心病合并糖尿病并行经皮冠状动脉介入治疗（percutaneous coronary intervention，PCI）的患者364例，男性261例，女性103例，145例植入可降解涂层药物洗脱支架，219例植入永久性涂层药物洗脱支架；对比术后两组患者主要不良心血管事件（main adverse cardiac events，MACE）的发生情况。结果两组患者在临床一般基线资料、冠脉病变特征等方面均无统计学差异（P0.05）。可降解涂层组与永久性涂层组相比，两组在心源性死亡(1.4% vs 1.9%)、非致死性心肌梗死(0.7% vs 0.9%)、支架内血栓(2.1% vs 2.3%)、靶血管血运重建(2.8% vs 2.8%)方面差异均无统计学意义（P0.05）。结论永久性涂层药物洗脱支架和可降解涂层药物洗脱支架治疗冠心病合并糖尿病患者均有效，且两者安全性无明显差异。

Abstract

Objective To compare the long-term efficacy and safety of biodegradable polymer and durable polymer drug-eluting stents (DES) in the patients with coronary heart disease and diabetes． Methods A total of 364 diabetic patients (261 males and 103 females) who underwent percutaneous coronary intervention (PCI) in our center from January 2008 to December 2012 were recruited in this study. In the cohort

145 patients were implanted with biodegradable polymer DES and 219 patients with durable polymer DES. Major adverse cardiac events (MACE) were observed and compared between the 2 groups. Results There were no significant differences in the baseline data and coronary artery lesion between the 2 groups (P0.05). Compared with the biodegradable polymer group

the permanent polymer group had similar safety and efficacy in cardiac death (1.4% vs 1.9%)

non-fatal myocardial infarction (0.7% vs 0.9%)

stent thrombosis (2.1% vs 2.3%) and target vessel revascularization (2.8% vs 2.8%

all P0.05). Conclusion Biodegradable polymer and durable polymer DES have the similar long-term efficacy and safety in the patients with coronary heart disease and diabetes.

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