Objective      To explore the relationship between mesenchymal-epithelial transition factor (c-Met) and epidermal growth factor receptor (EGFR) expression and postoperative recurrence in glottic laryngeal squamous cell carcinoma (LSCC).       Methods      Immunohistochemistry accompanied with H scores was utilized to evaluate the expression of c-Met and EGFR in primary focus tissues of 66 patients with glottic LSCC

who were equally divided into a recurrence group and a non-recurrence group. If H scores were greater than the median values

the c-met and EGFR expression was defined as high expression

and conversely

low expression was defined.       Results      The median values of H-scores of c-Met and EGFR were 150 (0-270) and 225 (0-270)

respectively. The univariate logistic regression analysis showed that the recurrence risk was significantly increased in the patients with high expression of c-Met or EGFR compared with the patients with low expression (OR=7.111

P0.001; OR=5.290

P=0.002). Stepwise regression analysis suggested that high expression of c-Met or EGFR was independent prognostic factor for recurrence after LSCC operation (OR=5.909

P=0.002; OR=4.231

P=0.013). ROC curve analysis showed that combined detection of c-Met and EGFR expression had moderate predictive value for postoperative recurrence (AUC=0.795

95%CI: 0.685-0.905).       Conclusion      The expression levels of c-Met and EGFR are closely correlated with postoperative recurrence of glottic LSCC

and can be used as indicators for recurrence of glottic LSCC.