Effect of repeated transcranial direct current stimulation on learning and memory ability in rat models of Alzheimer’s disease

俞雪鸿; 温惠中; 张运明; 黄晓倩; 唐媛恬; 田学隆

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Effect of repeated transcranial direct current stimulation on learning and memory ability in rat models of Alzheimer’s disease

更新时间：2026-01-09

- Effect of repeated transcranial direct current stimulation on learning and memory ability in rat models of Alzheimer’s disease
- Journal of Army Medical University Vol. 37, Issue 5, Pages: 449-453(2015)
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  CLC： R338.64;R454.1;R745.7
- Published：2015
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俞雪鸿,温惠中,张运明,黄晓倩,唐媛恬,田学隆.重复经颅直流电刺激对阿尔茨海默大鼠学习记忆能力的影响[J].陆军军医大学学报(原第三军医大学学报),2015,37(05):449-453.

　Yu Xuehong,Wen Huizhong,Zhang Yunming,Huang Xiaoqian,Tang Yuantian,Tian Xuelong.Effect of repeated transcranial direct current stimulation on learning and memory ability in rat models of Alzheimer’s disease[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(05):449-453.
俞雪鸿,温惠中,张运明,黄晓倩,唐媛恬,田学隆.重复经颅直流电刺激对阿尔茨海默大鼠学习记忆能力的影响[J].陆军军医大学学报(原第三军医大学学报),2015,37(05):449-453. DOI：

　Yu Xuehong,Wen Huizhong,Zhang Yunming,Huang Xiaoqian,Tang Yuantian,Tian Xuelong.Effect of repeated transcranial direct current stimulation on learning and memory ability in rat models of Alzheimer’s disease[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(05):449-453. DOI：

摘要

目的观察重复阳极经颅直流电刺激（transcranial direct current stimulation，tDCS)对阿尔茨海默病（Alzheimer’s disease，AD）大鼠学习记忆能力的影响。方法将36只SD大鼠分为假手术组、AD组、20 μA刺激组、60 μA刺激组、100 μA刺激组和200 μA刺激组，每组6只。AD组和刺激组的海马注射Aβ

1-40

制作AD模型。术后2周，刺激组接受重复阳极tDCS，而AD组和假手术组接受假刺激。tDCS后，用Morris水迷宫和Y迷宫检测大鼠学习记忆能力，尼氏染色观察大鼠海马神经元形态变化。结果 Morris水迷宫结果显示，60、100、200 μA刺激组的潜伏期均较AD组明显降低（P0.05）。大鼠经过原平台的次数和原平台象限游泳时间各组间差异并没有统计学意义（P0.05）。Y迷宫结果显示100 μA和200 μA刺激后，大鼠学习记忆成绩较AD组均有明显改善（P0.05）。尼氏染色显示tDCS后大鼠海马神经元胞质中尼氏体数量增加，染色加深。结论重复阳极tDCS能改善AD大鼠学习记忆功能障碍。

Abstract

Objective To investigate the effect of repeated anodal transcranial direct current stimulation (tDCS) on the learning and memories abilities in rat model of Alzheimer’s disease (AD). Methods Sprague-Dawley rats were randomly allocated to a sham group

an AD group

a 20 μA tDCS group

a 60 μA tDCS group

a 100 μA tDCS group and a 200 μA tDCS group. The hippocampi of the rats in the AD group and the tDCS groups was subjected to Aβ

1-40

injection to establish AD models. In postoperative 2 weeks

repeated a

nodal tDCS was applied to the frontal cortex of the rats in the tDCS groups

while the rats in the AD group and the sham group received sham stimulation. After tDCS

the learning and memory abilities of the rats was assessed by Morris water maze and Y-maze tests

and Nissl staining was performed to reveal morphological changes of hippocampus neurons. Results The Morris water maze test results showed that

compared with the AD group

the 60 μA tDCS group

100 μA tDCS group and 200 μA tDCS group showed significant decrease of the escape latency (P0.05)

but there were no significant changes in the platform-crossing times and swimming time in platform quadrant (P0.05). The Y-maze test results showed that

tDCS with current intensity of 100 μA and 200 μA significantly improved the learning and memory performance of the AD rats (P0.05). tDCS could increase the Nissl body number and deepen staining. Conclusion Repeated anodal tDCS may alleviate learning and memory dysfunction in the rat models of AD.

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