Behavioral characteristics during extinction of delay and trace eyeblink conditionings in guinea pigs

薛钰奇; 章利彬; 杨彦新; 胡陈; 陈浩; 胡波; 杨丽

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Behavioral characteristics during extinction of delay and trace eyeblink conditionings in guinea pigs

更新时间：2026-01-09

- Behavioral characteristics during extinction of delay and trace eyeblink conditionings in guinea pigs
- Journal of Army Medical University Vol. 37, Issue 4, Pages: 310-314(2015)
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  CLC： R-332;R338.61
- Published：2015
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薛钰奇,章利彬,杨彦新,胡陈,陈浩,胡波,杨丽.豚鼠延迟性和痕迹性眨眼条件反射消退的行为学特征[J].陆军军医大学学报(原第三军医大学学报),2015,37(04):310-314.

　Xue Yuqi,Zhang Libin,Yang Yanxin,Hu Chen,Chen Hao,Hu Bo,Yang Li.Behavioral characteristics during extinction of delay and trace eyeblink conditionings in guinea pigs[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(04):310-314.
薛钰奇,章利彬,杨彦新,胡陈,陈浩,胡波,杨丽.豚鼠延迟性和痕迹性眨眼条件反射消退的行为学特征[J].陆军军医大学学报(原第三军医大学学报),2015,37(04):310-314. DOI：

　Xue Yuqi,Zhang Libin,Yang Yanxin,Hu Chen,Chen Hao,Hu Bo,Yang Li.Behavioral characteristics during extinction of delay and trace eyeblink conditionings in guinea pigs[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(04):310-314. DOI：

摘要

目的研究消退过程中豚鼠眨眼条件反应特征参数的变化规律。方法 27只雄性12～16周龄豚鼠（体质量450～600 g），按随机抽签法分为：① 延迟性眨眼条件反射组（n=13）；② 痕迹性眨眼条件反射组（n=14）。使用2 kHz的正弦波纯音和医用氧气流分别作为条件刺激和非条件刺激，配对训练豚鼠建立延迟性和痕迹性眨眼条件反射。而后单独给予纯音条件刺激，使豚鼠已经建立的眨眼条件反射消退。高精度张力换能器记录豚鼠左侧的眼轮匝肌活动，Matlab程序分析眨眼运动行为数据。结果与痕迹组比较，延迟组动物条件眨眼反应习得率和条件眨眼反应峰幅度均显著增高（P0.05），但两组条件眨眼反应的消退速率没有显著区别（P0.05）。此外，延迟组豚鼠反射消退较痕迹组自发恢复更明显（P0.05）。结论延迟性和痕迹性眨眼条件反应的消退具有不同的行为学特征。

Abstract

Objective To investigate the behavioral characteristics of eyeblink responses during the extinction of delay and trace eyeblink conditionings in guinea pigs. Methods A total of 27 male guinea pigs (12-16 weeks-old

450-600 g) were randomly assigned into 2 groups

delay eyeblink conditioning group (n=13)

and trace eyeblink conditioning group (n=14). Pure tone conditioned stimulus (CS) of 2 kHz was paired with corneal oxygen-puff unconditioned stimulus (US) to acquire delay and trace conditioned eyeblink responses (CR). The guinea pigs received CS alone during the extinction. A high-resolution spring-return potentiometer was used to monitor the activities of left orbicularis oculi muscles. Self-developed software written in the Matlab environment was used to quantitatively analyze the behavioral data. Results Compared with the trace-conditioned guinea pigs

the delay-conditioned guinea pigs acquired faster CRs (P0.05) and higher peak amplitude (P0.05). Nevertheless

there was no significant difference in the CR extinction rate between the 2 groups (P0.05). In addition

more obvious spontaneous recovery of the extinguished CRs was observed in the delay-conditioned guinea pigs (P0.05) as compared to the trace-conditioned guinea pigs. Conclusion The behavioral characteristics of delay CR extinction are different from those of trace CR extinction.

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