Correlation of serum levels of VCAM-1 and MIF with early diabetic nephropathy: report of 126 cases

冯晓明; 田晓

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Correlation of serum levels of VCAM-1 and MIF with early diabetic nephropathy: report of 126 cases

更新时间：2026-01-09

- Correlation of serum levels of VCAM-1 and MIF with early diabetic nephropathy: report of 126 cases
- Journal of Army Medical University Vol. 36, Issue 16, Pages: 1729-1733(2014)
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  CLC： R446.112;R587.2;R692.04
- Published：2014
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冯晓明,田晓.血浆血管细胞黏附分子-1与巨噬细胞游走抑制因子水平与糖尿病患者肾脏功能损害的关联性研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(16):1729-1733.

　Feng Xiaoming,Tian Xiao.Correlation of serum levels of VCAM-1 and MIF with early diabetic nephropathy: report of 126 cases[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(16):1729-1733.
冯晓明,田晓.血浆血管细胞黏附分子-1与巨噬细胞游走抑制因子水平与糖尿病患者肾脏功能损害的关联性研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(16):1729-1733. DOI：

　Feng Xiaoming,Tian Xiao.Correlation of serum levels of VCAM-1 and MIF with early diabetic nephropathy: report of 126 cases[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(16):1729-1733. DOI：

摘要

目的探讨血管细胞黏附分子-1（vascular cell adhesion molecule-1，VCAM-1）和巨噬细胞游走抑制因子（macrophage migration inhibitory factor

MIF）对糖尿病患者的临床意义及其在糖尿病肾病诊断过程中的作用。方法选取2型糖尿病患者126例和20例健康体检者（健康对照组），测量VCAM-1、MIF、尿肌酐、血清肌酐等指标，估算糖尿病患者的肾小球滤过率（eGFR）。比较不同研究对象的VCAM-1与MIF水平，采用Pearson相关分析探讨VCAM-1及MIF与尿白蛋白/肌酐、eGFR的关联。结果糖尿病患者的VCAM-1、MIF水平明显高于健康对照组，尿白蛋白/肌酐越高，VCAM-1、MIF越高（

0.05）；VCAM-1和MIF水平与eGFR均呈明显的负相关关系（

=0.240 5

=0.516 2

0.05）；VCAM-1和MIF水平与尿白蛋白/肌酐值均呈正相关关系（

=0.069 5，

=0.059 5

0.05）；VCAM-1和MIF水平与eGFR变化均呈负相关（

=0.048 2

=0.071 7

0.05）。结论糖尿病及糖尿病肾病患者血浆中VCAM-1及MIF水平升高，对糖尿病肾病诊断及病情判断具有一定的参考价值。

Abstract

Objective To determine the clinical significance of vascular cell adhesion molecule-1 (VCAM-1) and macrophage migration inhibitory factor (MIF) in diabetic patients and determine their role in the diagnosis of diabetic nephropathy. Methods A total of 126 patients of type 2 diabetes in our department from Janu

ary 2010 to January 2012 were recruited in this study

and 20 healthy subjects were subjected as normal control. Their serum levels of VCAM-1

MIF and creatinine

urine creatinine and estimated glomerular filtration rate (eGFR) in diabetic patients were measured and calculated. VCAM-1 and MIF levels from different groups were compared and the correlation of MIF and VCAM-1 with urinary albumin/creatinine and eGFR was analyzed by Pearson correlation analysis. Results Serum levels of VCAM-1 and MIF were significantly higher in diabetic patients than the healthy control (

0.05)

and the higher the urinary albumin/creatinine

the higher VCAM-1 and MIF levels were (

0.05). Serum levels of VCAM-1 and MIF showed a significant negative correlation with eGFR (

=0.240 5

=0.516 2

0.05)

a positive correlation with urinary albumin/creatinine (

=0.069 5

=0.059 5

0.05); The changes of VCAM-1 and MIF levels compared with the levels in 1 year later showed a negative correlation with changes in eGFR (

=0.048 2

=0.071 7

0.05). Conclusion Serum levels of VCAM-1 and MIF are elevated in the patients with diabetes or diabetic nephropathy

and the levels provide a certain reference value for the diagnosis of diabetes and kidney disease.

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