E-cadherin expression in hepatocellular carcinoma and its effect on patients’ prognosis and survival: report of 79 cases

黄建强; 常瑞明; 温立强; 江志鹏; 常建星

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E-cadherin expression in hepatocellular carcinoma and its effect on patients’ prognosis and survival: report of 79 cases

更新时间：2026-01-09

- E-cadherin expression in hepatocellular carcinoma and its effect on patients’ prognosis and survival: report of 79 cases
- Journal of Army Medical University Vol. 36, Issue 22, Pages: 2301-2303(2014)
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  CLC： R730.43;R730.7;R735.7
- Published：2014
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黄建强,常瑞明,温立强,江志鹏,常建星.E-cadherin在肝癌组织中的表达及其对肝癌患者预后的影响[J].陆军军医大学学报(原第三军医大学学报),2014,36(22):2301-2303.

　Huang Jianqiang,Chang Ruiming,Wen Liqiang,Jiang Zhipeng,Chang Jianxing.E-cadherin expression in hepatocellular carcinoma and its effect on patients’ prognosis and survival: report of 79 cases[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(22):2301-2303.
黄建强,常瑞明,温立强,江志鹏,常建星.E-cadherin在肝癌组织中的表达及其对肝癌患者预后的影响[J].陆军军医大学学报(原第三军医大学学报),2014,36(22):2301-2303. DOI：

　Huang Jianqiang,Chang Ruiming,Wen Liqiang,Jiang Zhipeng,Chang Jianxing.E-cadherin expression in hepatocellular carcinoma and its effect on patients’ prognosis and survival: report of 79 cases[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(22):2301-2303. DOI：

摘要

目的探讨E-cadherin在肝癌组织中的表达及其在肝癌预后评判方面的价值。方法收集南方医科大学中西医结合医院外二科2005年1月至2009年6月接受肝脏手术的肝癌患者79例，男性69例，女性10例，年龄23～78（51.69±12.84）岁。用Western blot方法检测5对肝癌及癌旁组织中E-cadherin的蛋白水平。免疫组化技术检测79例肝癌组织中E-cadherin的蛋白表达水平，分析E-cadherin表达与组织学分级的相关性，并通过Kaplan-Meier方法和Log rank检验比较不同E-cadherin表达水平患者的预后。结果在5对肝癌及癌旁组织中，有3例患者肝癌组织E-cadherin低表达。79例肝癌中有64例存在E-cadherin低表达，且肝癌组织中E-cadherin表达明显低于正常肝组织(P0.01)。肝癌中E-cadherin低表达与高的组织学分级相关(P=0.028)，且E-cadherin低表达组预后较中/高表达组差(P=0.040 9)。结论肝癌组织中E-cadherin低表达提示患者不良预后。

Abstract

Objective To investigate the expression of E-cadherin and its prognostic significance in hepatocellular carcinoma (HCC) samples. Methods Seventy-nine HCC patients undergoing surgical resection in our department from January 2005 to June 2009 were enrolled in this study. They were 69 males and 10 females

at a mean age of 51.69±12.84 (ranging from 23 to 78). The protein levels of E-cadherin were detected in 5 paired specimens of HCC and para-carcinaoma tissues by Western blotting

and in all 79 HCC tissues by immunohistochemical assay. The correlation of E-cadherin status with histological grade was analyzed. In addition

Kaplan-Meier and Log rank methods were employed to compare the prognosis among the patients with different E-cadherin expression levels. Results Among 5 paired HCC and para-carcinoma tissues

3 cases had low expression of E-cadherin in tumor tissues. Compared with normal liver tissues

the E-cadherin expression was significantly lower in the liver cancer tissues(P0.01)

and lower E-cadherin expression was associated with high histological grade(P=0.028). Sixty-four of 79 HCC patients (81.0%) showed low levels of E-cadherin. Lower E-cadherin expression was associated with poorer prognosis in HCC(P=0.040 9). Conclusion The protein level of E-cadherin is down-regulated in HCC

and its low level predicts poor prognosis.

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