Expression of AZGP1 protein and its relationship with prognosis in esophageal squamous cell carcinoma

姚传山; 马磊; 赵旭林; 李芳芳; 贺利民

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Expression of AZGP1 protein and its relationship with prognosis in esophageal squamous cell carcinoma

更新时间：2026-01-09

- Expression of AZGP1 protein and its relationship with prognosis in esophageal squamous cell carcinoma
- Journal of Army Medical University Vol. 37, Issue 1, Pages: 51-54(2015)
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  CLC： R341;R730.23;R735.1
- Published：2015
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姚传山,马磊,赵旭林,李芳芳,贺利民.锌-α2-糖蛋白在食管鳞癌组织中的表达及预后意义[J].陆军军医大学学报(原第三军医大学学报),2015,37(01):51-54.

　Yao Chuanshan,Ma Lei,Zhao Xulin,Li Fangfang,He Limin.Expression of AZGP1 protein and its relationship with prognosis in esophageal squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(01):51-54.
姚传山,马磊,赵旭林,李芳芳,贺利民.锌-α2-糖蛋白在食管鳞癌组织中的表达及预后意义[J].陆军军医大学学报(原第三军医大学学报),2015,37(01):51-54. DOI：

　Yao Chuanshan,Ma Lei,Zhao Xulin,Li Fangfang,He Limin.Expression of AZGP1 protein and its relationship with prognosis in esophageal squamous cell carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(01):51-54. DOI：

摘要

目的研究锌-α2-糖蛋白(Zn-alpha2-glycoprotein

ZGP1)在食管鳞状细胞癌(esophageal squamous cell carcinoma

ESCC)组织中的表达及AZGP1蛋白表达水平对患者预后的影响。方法采用免疫组织化学方法检测112例食管鳞癌组织及25例癌旁正常食管黏膜组织中AZGP1蛋白的表达。分析食管鳞癌组织中AZGP1蛋白表达与临床病理特征的关系及对患者预后的影响。结果 ESCC组织中AZGP1蛋白高表达率低于癌旁正常食管黏膜组织(47.3% vs 76.0%，χ

=6.741，P=0.008)；在高-中分化（60.9%）、T1~3分期（61.7%）及临床分期Ⅰ期+Ⅱ期（58.3%）食管鳞癌组织中AZGP1蛋白高表达多(P0.05)；生存分析表明，AZGP1蛋白高表达组较低表达组具有生存优势，无进展生存期（progression-free survival

PFS）及总生存期（overall survivaL

OS）均延长，差异有统计学意义(P0.05)。结论 AZGP1蛋白高表达可能对ESCC有抑制作用，AZGP1蛋白表达水平可预测ESCC患者的预后。

Abstract

Objective To determine the expression and prognostic value of Zn-alpha2-glycoprotein (AZGP1) in esophageal squamous cell carcinoma (ESCC). Methods A total of 112 ESCC patients who admitted in the department of thoracic surgery of our hospital from January 2008 to June 2010 were enrolled in this study

and they were all followed up till April 2014. The expression of AZGP1 in their samples of ESCC and 25 adjacent normal esophageal mucosa were detected by immunohistochemistry. Correlations of the expression of AZGP1 in the ESCC with their clinical features and prognosis were analyzed with statistical program SPSS 17.0. Results The high expression of AZGP1 protein was significantly lower in the ESCC tissues than the adjacent normal esophageal mucosa (47.3% vs 76.0%

Chi square=6.741

P=0.008). The high expression was found in the tumors of high and moderate differentiation (60.9%)

of T1-3 stage (61.7%) and clinical stages Ⅰ+Ⅱ (58.3%) (all P0.05). Univariate survival analysis suggested that progression-free survival (PFS) and overall survivaL (OS) were better in the patients with high AZGP1 protein than those with lower (P0.05). Conclusion High AZGP1 protein expression may have some inhibitory effect on ESCC

and its the expression level may predict the prognosis of ESCC patients.

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