Quantitative expression of Ascl2 and microRNA-200 in colorectal cancer and their peri-cancerous mucosa and their correlation

李姗姗; 钟小莉; 尚阳阳; 潘琼; 叶钧; 汪荣泉

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Quantitative expression of Ascl2 and microRNA-200 in colorectal cancer and their peri-cancerous mucosa and their correlation

更新时间：2026-01-09

- Quantitative expression of Ascl2 and microRNA-200 in colorectal cancer and their peri-cancerous mucosa and their correlation
- Journal of Army Medical University Vol. 36, Issue 23, Pages: 2377-2379(2014)
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  CLC： R394.3;R730.23;R735.35
- Published：2014
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李姗姗,钟小莉,尚阳阳,潘琼,叶钧,汪荣泉.Ascl2和microRNA-200家族在结肠癌组织和癌旁组织中的定量表达及二者的相关性分析[J].陆军军医大学学报(原第三军医大学学报),2014,36(23):2377-2379.

　Li Shanshan,Zhong Xiaoli,Shang Yangyang,Pan Qiong,Ye Jun,Wang Rongquan.Quantitative expression of Ascl2 and microRNA-200 in colorectal cancer and their peri-cancerous mucosa and their correlation[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(23):2377-2379.
李姗姗,钟小莉,尚阳阳,潘琼,叶钧,汪荣泉.Ascl2和microRNA-200家族在结肠癌组织和癌旁组织中的定量表达及二者的相关性分析[J].陆军军医大学学报(原第三军医大学学报),2014,36(23):2377-2379. DOI：

　Li Shanshan,Zhong Xiaoli,Shang Yangyang,Pan Qiong,Ye Jun,Wang Rongquan.Quantitative expression of Ascl2 and microRNA-200 in colorectal cancer and their peri-cancerous mucosa and their correlation[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(23):2377-2379. DOI：

摘要

目的探讨Ascl2与MicroRNA-200家族在结肠癌 (colorectal cancer，CRC）组织及癌旁组织中的表达及二者的相关性。方法采用实时定量PCR检测50例结肠癌患者的结直肠癌组织及其癌旁组织中Ascl2与MicroRNA-200家族表达，用SPSS 18.0统计软件进行统计分析。结果 Ascl2在癌组织中的表达显著高于癌旁组织（P0.01），除了MicroRNA-429 在癌组织中的表达与癌旁组织相比无统计学差异（P=0.2139），MicroRNA-200家族成员在癌组织中的表达都显著低于癌旁组织（P0.05）；且Ascl2和MicroRNA-200家族成员在癌组织中表达都呈负相关（rP0.05）。结论发现与正常结直肠黏膜组织相比，Ascl2在结直肠癌组织中表达增高， MicroRNA-200家族表达降低，它们在结直肠癌组织中的表达呈现负相关。

Abstract

Objective To investigate the expression of Ascl2 and microRNA-200 family members in colorectal cancer and their peri-cancerous mucosa tissues and determine their correlations. Methods The expression of Ascl2 mRNA and microRNA-200 family members in 50 colorectal cancer samples and their peri-cancerous mucosa was detected by real time-PCR. Statistical analysis was performed by SPSS 18 statistical software. Results The mRNA expression level of Ascl2 was significantly higher in cancerous samples than the corresponding peri-cancerous mucosa (P0.01)

while the levels of microRNA-200 family members were significantly lower in cancerous samples than the peri-cancerous mucosa (P0.05)

except that no difference was found in microRNA-429 expression between the 2 tissue samples (P=0.2139). The expression level of Ascl2 was negatively correlated with those of microRNA-200 family members (rP0.05). Conclusion The expression level of Ascl2 is increased

while those of microRNA-200 family members are decreased in colorectal cancer tissues when compared with the corresponding peri-cancerous tissues. And the expression levels are negatively correlated.

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