Preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system

甘露; 田睿; 贾运涛; 郭锋; 邓萍; 张良珂

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Preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system

更新时间：2026-01-09

- Preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system
- Journal of Army Medical University Vol. 36, Issue 22, Pages: 2263-2266(2014)
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  CLC： R282.71;R943;R944.9
- Published：2014
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甘露,田睿,贾运涛,郭锋,邓萍,张良珂.和厚朴酚自微乳结冷胶钙微丸的制备及其特性研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(22):2263-2266.

　Gan Lu,Tian Rui,Jia Yuntao,Guo Feng,Deng Ping,Zhang Liangke.Preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(22):2263-2266.
甘露,田睿,贾运涛,郭锋,邓萍,张良珂.和厚朴酚自微乳结冷胶钙微丸的制备及其特性研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(22):2263-2266. DOI：

　Gan Lu,Tian Rui,Jia Yuntao,Guo Feng,Deng Ping,Zhang Liangke.Preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(22):2263-2266. DOI：

摘要

目的制备载和厚朴酚自微乳结冷胶钙微丸(calcium-gellan beads containing honokiol self-microemulsifying drug delivery system

GB-HSMEDDS)，研究其特性。方法采用离子凝胶法制备GB-HSMEDDS，以包封率为指标，单因素实验考察结冷胶浓度、钙离子浓度、交联时间、投药量对药物包封率的影响，对优化后的微丸在HCl（pH 1.2）及PBS（pH 6.8）溶液中的溶胀及释放特性进行研究。结果通过优化，选取结冷胶浓度为1.25%，CaCl2浓度8%，和厚朴酚自微乳化给药系统（self-microemulsifying drug delivery system

SMGDDS)与结冷胶溶液质量比(g/g)为0.15，交联时间15 min为制备条件，包封率为(64.0±2.8)%，微丸在PBS中的溶胀度大于在HCl溶液中的，药物在HCl溶液中2 h的累积释放超过50%，而在PBS中的不足20%。结论成功制备了含和厚朴酚SMEDDS的结冷胶钙微丸，有望成为SMEDDS固体化的良好载体。

Abstract

Objective To study the preparation and characterization of calcium-gellan beads containing honokiol self-microemulsifying drug delivery system (GB-HSMEDDS). Methods GB-HSMEDDS were prepared by ionotropic gelation. With the encapsulation efficiency as indicators

the concentration of gellan gum and Ca

cross-linking time and amount of added drug were selected as variables for single-factor experiment design. The swelling and release characteristics of the beads at pH 1.2 and 6.8 were investigated. Results T

he optimal preparation method included: gellan gum concentration 1.25%

CaCl

concentration 8%

the weight ratio of honokiol microemulsifying drug delivery system (SMEDDS) to gellan gum solution 0.15

and the cross-linking time 15 min. The encapsulation efficiency of GB-HSMEDDS was (64.0±2.8)%. The swelling degree of GB-HSMEDDS in PBS was greater than those in HCl solution. The cumulative release of honokiol was more than 50% in HCl solution but less than 20% in PBS for 2 h. Conclusion We successfully prepare gellan gum beads containing honokiol SMEDDS

a good carrier for producing solid SMEDDS.

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