Objective       To determine the clinical efficacy of perioperative multimodal analgesia in the patients undergoing posterior lumbar fusion surgery with internal instrumentation.       Methods       From July 2011 to December 2012

64 patients scheduled for posterior lumbar fusion surgery with internal instrumentation were prospectively recruited in the study

and randomly divided into 2 groups

multimodal analgesia group (group M

n=32) and single intravenou

s patient controlled analgesia (PCA) group (group S

n=32). The multimodal analgesia regimen included preoperative celecoxib

local infiltration analgesia with ropivacaine

PCA and postoperative parecoxib. Visual analogue scale (VAS) scores at rest were recorded in 3

12

24

and 48 h postoperatively. Patient pain levels during the first ambulation and discharge were also documented. The number of PCA attempts

drug dosage in PCA

satisfaction rate

requirement for rescue analgesic and adverse events were also recorded.       Results       Compared with group S

the VAS scores were significantly decreased at 3

12

24 and 48 h after surgery and at the first ambulation

and the satisfaction rate was increased in group M (

P

0.05). The number of PCA attempts

drug dosage in PCA and incidences of adverse effects were obviously lower in group M than in group S (

P

0.05). There was no significant difference in the amount of drainage between the 2 groups (

P

0.05). No serious postoperative complication occurred in either group.       Conclusion       Multimodal analgesia is a safe and effective analgesic regimen for the patients undergoing posterior lumbar fusion surgery with internal instrumentation. Patients demonstrate better pain scores and lower opioids requirements.