CD44, CD133 and TF correlate with formation of portal vein tumor thrombus and poor prognosis in patients with hepatocellular carcinoma

陈凯; 李中虎; 江鹏; 张曦; 张玉君; 江艳; 李晓武

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CD44, CD133 and TF correlate with formation of portal vein tumor thrombus and poor prognosis in patients with hepatocellular carcinoma

更新时间：2026-01-09

- CD44, CD133 and TF correlate with formation of portal vein tumor thrombus and poor prognosis in patients with hepatocellular carcinoma
- Journal of Army Medical University Vol. 36, Issue 10, Pages: 1068-1073(2014)
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  CLC： R341;R730.43;R735.7
- Published：2014
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陈凯,李中虎,江鹏,张曦,张玉君,江艳,李晓武.CD44、CD133和TF与肝癌中门静脉癌栓形成及恶性预后相关[J].陆军军医大学学报(原第三军医大学学报),2014,36(10):1068-1073.

　Chen Kai,Li Zhonghu,Jiang Peng,Zhang Xi,Zhang Yujun,Jiang Yan,Li Xiaowu.CD44, CD133 and TF correlate with formation of portal vein tumor thrombus and poor prognosis in patients with hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(10):1068-1073.
陈凯,李中虎,江鹏,张曦,张玉君,江艳,李晓武.CD44、CD133和TF与肝癌中门静脉癌栓形成及恶性预后相关[J].陆军军医大学学报(原第三军医大学学报),2014,36(10):1068-1073. DOI：

　Chen Kai,Li Zhonghu,Jiang Peng,Zhang Xi,Zhang Yujun,Jiang Yan,Li Xiaowu.CD44, CD133 and TF correlate with formation of portal vein tumor thrombus and poor prognosis in patients with hepatocellular carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(10):1068-1073. DOI：

摘要

目的探讨肝癌干细胞表面标志物CD44、CD133与组织因子（tissue factor

TF）在肝癌组织中的表达及分析其与肝癌临床病理资料及生存预后间的相互关系。方法应用免疫组化法检测387例肝癌组织中CD44、CD133和TF的表达，比较其表达与肝癌临床病理资料及预后间的关系。结果 ①387例肝癌组织中CD44、CD133和TF的阳性率分别为60.47％、55.81％和65.12％；CD44与CD133双阳性表达（CD44

CD133

）阳性率41.60％； CD44、CD133和TF三阳性表达（CD44

CD133

）阳性率35.14％；②CD44、CD133与TF单独阳性表达以及CD44

CD133

和CD44

CD133

均与肝癌患者门静脉癌栓、TNM 分期和Edmendson分级具显著相关性(

0.01)； ③ CD90、CD44和CD133蛋白表达呈正相关(

0.01)；④CD44、CD133和TF阳性组的总生存时间短于阴性组，差异有统计学意义(

0.05)；CD44

CD133

组总生存时间短于非CD44

CD133

组总生存时间及CD44

CD133

组总生存时间短于非CD44

CD133

组，差异均有统计学意义(

0.01);⑤多因素分析门静脉癌栓、TF

、CD44

CD133

和CD44

CD133

是影响肝癌预后的独立危险因数(

0.01)。结论 CD44、CD133和TF均与门静脉癌栓形成及恶性预后密切相关，可作为判断患者预后的指标。

Abstract

Objective Investigat

e the expression of CD44

CD133 and tissue factor (TF) and their clinicopathologic significance in hepatocellular carcinoma (HCC). Methods The expression of CD44

CD133 and TF was detected using immunohistochemistry in 387 liver tissue samples from HCC patients. We further evaluated the relationship between the expression and clinical pathology and prognosis of HCC. Results The positive expression rates of CD44

CD133 and TF in HCC patients were 60.47%

55.81%

and 65.12%

respectively. The positive rate of co-expression of CD44 and CD133 (CD44

CD133

) was 41.60%. The positive rate of co-expression of CD44

CD133 and TF (CD44

CD133

) was 35.14%. Clinical analysis showed that single expression of CD44

CD133 or TF was associated with portal vein tumor thrombus

TNM staging and grading of Edmendson. CD44

CD133

and CD44

CD133

had the same results (

0.01 and

0.01

respectively). The difference of survival rate between CD44-positive and CD44-negative groups was observed

and the CD133-positive and CD133-negative groups as well as the TF-positive and TF-negative groups had the same result (

0.01 all). The protein expression CD90

CD44 and CD133 was positively correlated (

0.01). The total survival time of CD44

CD133 and TF positive groups was shorter than the negative groups and the differences were statistically significant (all

0.01). The total survival time of CD44

CD133

group was shorter than that of non-CD44

group (

0.01). The total survival time of CD44

CD133

group was shorter than that of non-CD44

CD133

group and the differences were statistically significant (P0.01). Multivariate analysis suggested that portal vein tumor thrombus

CD44

CD133

and CD44

CD133

were the independent risk factors of the prognosis of HCC (

0.01 all). Conclusion The positive expression of CD44

CD133 and TF is associated with each other and closely correlated with the formation of portal vein tumor thrombus

indicating the poor prognosis of HCC.

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