Objective      To evaluate the short-term clinical efficacy and safety of laparoscopic Roux-en-Y gastric bypass (LRYGB) in obese patients with type 2 diabetes mellitus (T2DM).       Methods        Twelve obese T2DM patients undergoing LRYGB from May 2010 to August 2013 were recruited in this study. They were 4 males and 8 females

with a mean age of 43.8±10.6 years

a mean duration of T2DM for

8.3±3.9 years

a body mass index of 31.3±5.6 kg/m

2

fasting plasma glucose of 9.4±1.9 mmol/L

and HbA1c of (8.4±1.6)% before surgery. The cohort was followed up for a period of 12 months. Main outcome measures were the rate of diabetes remission (complete remission of diabetes was defined as a fasting plasma glucose level of less than 7.0 mmol/L and HbA1c level less than 6.5% without active pharmacologic therapy). Data on demographics

lipid profiles

blood pressure

levels glucose and HbA1c

medication

and remission were prospectively collected and analyzed with post-operative data.       Results      In 12 months after LRYGB

there were significant decreases in body weight (20.4±9.7 kg)

waist circumference (23.4±14.1 cm)

and in HbA1c [(2.1±1.7)%

]

. There were 7 patients (58.3%) having T2DM complete remission

and 5 (41.7%) with partial remission. For the patients complicated with hypertension and/or dyslipidemia

their antihypertensive agents and lipid-lowering drugs were stopped to use after surgery. The group achieving T2DM complete remission had a shorter duration of diabetes compared with the partial remission group（4.6±3.3 years vs 10.6±3.7 years，

P

0.05）. There was no mortality

and one (8.3%) patient experienced early complications and another one (8.3%) with the long-term complications.       Conclusion        LRYGB has satisfying short-term outcomes in the treatment of obese T2DM

with well control on blood glucose

lipids and bood pressure.