Objective        To investigate the correlati

on of serum level of gamma glutamine transferase (GGT) with the severity of coronary artery lesions in patients with type 2 diabetes accompanied with coronary artery diseases (CHD) and explore the significance of serum GGT in evaluation of CHD.       Methods        A total of 226 patients with type 2 diabetes who receiving coronary angiography in our hospital from March 2012 to March 2013 were recruited in this study. These patients were divided into coronary lesions group  calculated with the Gensini score) and normal coronary artery group according to the results of selective coronary angiography. The serum level of GGT was measured

and other risk factors and components of CHD

such as body mass index (BMI)

low-density lipoprotein cholesterol (LDL-c)

and insulin-C peptide were also detected.       Results        Among these 226 patients

there were statistical significance in the age

BMI

LDL-c

HDL-c

GGT

insulin-C peptide and Gensini score between the coronary lesion group and normal coronary artery group (

P

0.05)

while there was no difference in other factors such as gender

Glu

systolic pressure

diastolic pressure

TC

TG

AST

ALT

serum creatinine

serum albumin between them. According to the level of the Gensini score

the coronary lesion group were further divided into 3 subgroups

i.e.

the high (40)

middle (20 to 40)

and low (20) score groups

and the normal coronary group was employed for comparative analysis. The GGT level of all subgroups and normal control group was statistically difference (

P

0.01)

whereas for the insulin-C peptide

only the high group and normal control group had statistically significant (

P

0.01). What′s more

both levels of GGT and insulin-C peptide were significantly higher in the high score group than in the middle and low score groups (

P

0.01). In the type 2 diabetic patients with coronary artery disease

the levels of plasma LDL-c and serum GGT were positively correlated with the coronary artery narrow degree (r=0.373，

P

0.01; r=0.26

4，

P

0.01). In ROC curve analysis

the area under curve (AUC) for GGT was 0.674 (ranged 0.598 to 0.750) for coronary lesion group

significantly lower than that of BMI (0.703)

LDL-c (0.687)

and higher than that of age (0.640)

insulin-C peptide (0.592)

and HDL-c (0.379).       Conclusion       The serum level of GGT is positively associated with the degree of coronary artery lesions in patients with type 2 diabetes mellitus and coronary heart disease

and can be used as an independent predictor of coronary risk.