Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion

徐胤; 王璞; 沈才飞; 李婧文; 张安然; 邵顺子; 于晓娜; 张昊翔; 闫武; 夏一菊; 房殿春

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Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion

更新时间：2026-01-09

- Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion
- Journal of Army Medical University Vol. 36, Issue 9, Pages: 873-877(2014)
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  CLC： R341;R730.23;R735.1
- Published：2014
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徐胤,王璞,沈才飞,李婧文,张安然,邵顺子,于晓娜,张昊翔,闫武,夏一菊,房殿春.食管鳞癌及癌前病变组织中紧密连接蛋白claudin3和4的表达及临床病理意义[J].陆军军医大学学报(原第三军医大学学报),2014,36(09):873-877.

　Xu Yin,Wang Pu,Sheng Caifei,Li Jingwen,Zhang Anran,Shao Shunzi,Yu Xiaona,Zhang Haoxiang,Yan Wu,Xia Yiju,Fang Dianchun.Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(09):873-877.
徐胤,王璞,沈才飞,李婧文,张安然,邵顺子,于晓娜,张昊翔,闫武,夏一菊,房殿春.食管鳞癌及癌前病变组织中紧密连接蛋白claudin3和4的表达及临床病理意义[J].陆军军医大学学报(原第三军医大学学报),2014,36(09):873-877. DOI：

　Xu Yin,Wang Pu,Sheng Caifei,Li Jingwen,Zhang Anran,Shao Shunzi,Yu Xiaona,Zhang Haoxiang,Yan Wu,Xia Yiju,Fang Dianchun.Expression and clinicopathological significance of claudin 3 and 4 in esophageal squamous carcinoma and precancerous lesion[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(09):873-877. DOI：

摘要

目的检测紧密连接蛋白claudin3、claudin4在食管鳞状细胞癌及癌前病变组织中的表达，探讨二者表达的临床病理学意义。方法应用组织芯片联合免疫组化EnVision法检测claudin3、claudin4在93例食管鳞癌、20例异型增生组织、20例食管炎和15例正常食管上皮组织中的表达水平。结果 claudin3在正常食管上皮、食管炎、异型增生及食管鳞癌中的表达率分别为6.7%(1/15)、20.0%(4/20)、30.0%(6/20)、43.0%(40/93)，癌组织阳性率最高，正常食管上皮组织阳性率最低，差异有统计学意义（

0.05）

食管癌阳性率较正常食管上皮明显升高（

0.05），异型增生及食管炎的表达较正常组织差异并无显著性(

0.05)。claudin4在正常食管上皮、食管炎、异型增生及食管鳞癌中的表达率分别为33.3%（5/15）、35.0%(7/20)、40.0%（8/20）、45.2%（42/93），各组间差异无统计学意义（

0.05）。claudin3和claudin4表达与患者的性别、年龄、肿瘤大小、病理分级及浸润深度无相关性（

0.05），但有淋巴结转移者的阳性率较无淋巴结转移者低(

0.05)，且死亡组的阳性率较生存组低(

0.05)；claudin3和claudin4在食管鳞癌中表达存在显著相关性（χ

=8.520，K=0.302，

=0.004），但两种表达无统计学差异（

0.05）;生存分析发现claudin3和claudin4表达阳性组的术后生存率高于表达阴性组 (

0.05)。结论 claudin3可能参与了食管鳞癌的发生，有淋巴结转移时claudin3和claudin4的表达出现下调，claudin3和claudin4有可能成为判断食管鳞癌预后的分子标志物。

Abstract

Objective To determine the expression of claudin 3 and claudin 4 in esophageal squamous carcinoma and its precancerous lesion

and investigate the clinicopathological s

ignificance of the expression. Methods Tissue microarray technology and immunohistochemical assay (Envision) were used to detect the expression of claudin 3 and 4 in 93 tissue samples of esophageal squamous carcinoma

20 samples of dysplasia

20 samples of esophagitis and 15 cases of normal esophageal mucosal tissues. Results Claudin 3 was expressed in only 1 case of normal esophageal mucosa (6.7%)

4 cases of esophagitis (20.0%)

6 cases of dysplasia (30.0%) and 40 cases of squamous carcinoma (43.0%). The positive rate was the highest in cancer tissue

and the lowest in normal esophageal tissue

with significant difference between them (

0.05). The rate was obviously higher in the cancer tissue than in normal tissue (

0.05)

but no difference was seen among the normal tissue

dysplasia and esophagitis tissue (

0.05). Claudin 4 expression was found in 5 cases of normal esophageal mucosa (33.3%)

7 cases of esophagitis (35.0%)

8 cases of dysplasia (40.0%) and 42 cases of squamous carcinoma (45.2%)

without significant difference among these groups (

0.05). The expression of claudin 3 and 4 was not associated with other clinicopathologic factors

such as sex

age

tumor size

pathological grade and infiltration (

0.05)

but obviously negatively associated with lymphatic metastasis and patient survival (

0.05). The expression of claudin 3 and 4 was significantly correlated with each other (Chi-sqaure=8.520

K=0.302

=0.004)

but had no significant difference in esophageal squamous carcinoma (

0.05). Kaplan-Meier survival analysis showed that the survival rate in patients with claudin3 and 4 expression was significantly higher than those without (

0.05). Conclusion Claudin 3 may participate in the occurrence of esophageal squamous carcinoma. Down-regulation of claudin 3 and 4 is associated with lymphatic metastasis in esophageal squamous carcinoma

and they might serve as potential markers for prognosis of

esophageal squamous carcinoma.

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