Expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer

熊艳丽; 杨雪琴; 张诗珩; 杨宇馨; 冯燕; 黄环; 王东

您当前的位置：

首页 >

文章列表页 >

Expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer

更新时间：2026-01-09

- Expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer
- Journal of Army Medical University Vol. 36, Issue 10, Pages: 983-986(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R341;R730.23;R734.2
- Published：2014
- 稿件说明：
移动端阅览
熊艳丽,杨雪琴,张诗珩,杨宇馨,冯燕,黄环,王东.Nm23-H1在小细胞肺癌中的表达及其与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2014,36(10):983-986.

　Xiong Yanli,Yang Xueqin,Zhang Shiheng,Yang Yuxin,Feng Yan,Huang Huan,Wang Dong.Expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(10):983-986.
熊艳丽,杨雪琴,张诗珩,杨宇馨,冯燕,黄环,王东.Nm23-H1在小细胞肺癌中的表达及其与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2014,36(10):983-986. DOI：

　Xiong Yanli,Yang Xueqin,Zhang Shiheng,Yang Yuxin,Feng Yan,Huang Huan,Wang Dong.Expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(10):983-986. DOI：

摘要

目的探讨肿瘤转移抑制因子Nm23-H1在小细胞肺癌（small cell lung cancer， SCLC）中的表达及其与预后的关系。方法通过免疫组化S-P法检测71例SCLC组织和22例正常肺组织中Nm23-H1蛋白表达情况，根据染色强度和阳性肿瘤细胞数目所占百分比，将其分为高、低表达两组，使用SPSS 19.0软件统计分析Nm23-H1的表达与临床病理及预后的关系。结果正常肺组织中Nm23-H1蛋白表达显著高于SCLC组织（90.9% vs 57.7%，

0.01）；局限期患者Nm23-H1蛋白表达显著高于广泛期患者（66.7% vs 39.1%，

0.05）。多因素Logistic回归分析显示，Nm23-H1蛋白可作为SCLC是否转移的独立保护因素（OR=0.32， 95%CI=0.12~0.90，

0.05）。亚细胞定位在正常肺组织与肺癌组织中没有差异，在不同分期之间也没有差异。多因素COX风险回归分析表明只有临床分期为广泛期和年龄≥60岁是SCLC患者总生存的劣势预后因素（年龄：HR=1.03，95%CI=1.00~1.05，

0.05；临床分期：HR=1.85，95%CI=1.03~3.33，

0.05）。Nm23-H1蛋白表达及亚细胞定位与SCLC患者生存期都没有显著相关性。结论 Nm23-H1在SCLC组织中以细胞质表达为主的低表达，低表达与SCLC的远处转移密切相关，可能是SCLC预后不良的指标之一。

Abstract

Objective To study the expression of Nm23-H1 and its relationship with prognosis in patients with small cell lung cancer. Methods The expression of Nm23-H1 was detected by immunohistochemistry in 71 small cell lung cancer tissue samples and 22 normal lung tissue samples. According to their positive percentage and staining intensity

they were divided into 2 groups：high expression gro

up and low expression group. The correlation of Nm23-H1 expression with clinicopathology and prognosis was performed by SPSS 19.0. Results The positive rate of Nm23-H1 was higher in normal tissue samples than in small cell lung cancer（90.9% vs 57.7%，

0.05）；It was higher in limited stage than in extensive stage small cell lung cancer（66.7% vs 39.1%，

0.05）。 Multivariate logistic regression showed the Nm23-H1 expression was an independent protect factor for the metastasis of small cell lung cancer (OR=0.32

95% CI=0.12-0.90，

0.05). The subcellular location of the Nm23-H1 showed no difference between normal lung tissues and cancer tissues

neither between different stages. In the survival analysis

Nm23-H1 positive expression was found to be related with decreased median overall survival than negative expression patients (

0.05). The stage was also associated with mOS that the patients with limited foci stayed longer than those with metastastic diesease (HR=1.85

95% CI=1.03-3.63

0.05). Conclusion Nm23-H1 is midly expressed in SCLC cancer tissues

and mainly in the cytoplasma. The expression plays an important role in the metastasis of SCLC

and may be a predictive factor for the poor outcome of SCLC.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of extensive small cell lung cancer metastasis on patient’s survival

Relationship of base excision repair pathway-related proteins with immune cell infiltration and prognosis in small cell lung cancer

Serum uPAR and its relationship with chemosensitivity and prognosis in patients with small cell lung cancer

Expression of human 8-hydroxyguanine deoxyribonucleic acid glycosidase 1 in small cell lung cancer and its correlation with prognosis

A novel estrogen receptor expression stratification (low/moderate/high) based on Chinese population provides more accurate prognosis prediction for HR⁺/HER2^- early breast cancer patients

Related Author

李玮

林萍

王骐

LI Chaofan

CHEN Tianyi

CHEN Qian

YANG Yuxin

WANG Dong

Related Institution

Cancer Center， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of Breast and Thyroid Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Gastroenterology， Chongqing Hechuan District People’s Hospital

School of Medicine， Chongqing University

Chongqing Key Laboratory of Precision Prevention and Treatment for Digestive System Tumors， Department of Gastroenterology， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

⁰