Objective        To investigate the effects of octreotide on tumour necrosis factor alpha (TNF-α)

interleukin 6 (IL-6)

sur

factant protein D (SP-D)

oxygenation index (OI) and respiratory index (RI) in patients during peri-operative period of hepatic lobectomy.       Methods        Forty ASA Ⅱ or Ⅲ patients scheduled for hepatic lobectomy in Southwest hospital from February to December 2013 were enrolled in this study. Then they were randomly divided into octreotide group and control (n=20). The same standard anesthesia protocol was used for induction and maintenance in all 2 groups. After anesthesia induction

the octreotide group was given 0.1 mg octreotide intravenously followed by 0.5 mg/60 mL by pain pump until the end of the surgery. While the patients of control were given same volume of normal saline through same approach. Arterial blood samples were collected for blood gas analysis before induction of anesthesia (T

0

)

10 min after cutting skin (T

1

)

30 min after recuperating liver blood flow (T

2

)

and l (T

3

) and 24 h (T

4

) after operation. OI and RI were calculated. Plasma TNF-α

IL-6 and SP-D were measured at T

0

T

1

T

2

T

3

and T

4

.       Results        Compared with T

0

the plasma levels of TNF-α

IL-6 and SP-D and RI were significantly increased

while the OI was significantly decreased at T

2

to T

4

in the 2 groups (

P

0.05). The plasma level of TNF-α

IL-6 and SP-D and RI in the octreotide group were significantly lower

while the OI was obviously higher than those in the control group at T

2

to T

4

(

P

0.05).       Conclusion        Octreotide attenuates the lung injury and protects lung function induced by hepatic lobectomy

which probably through inhibiting inflammatory response.