Expression of programmed cell death gene 4 in triple-negative breast cancer and its relationship with prognosis

韩晓蓉; 王颀; 吴坤河; 谢四梅; 连臻强; 黄宗海

您当前的位置：

首页 >

文章列表页 >

Expression of programmed cell death gene 4 in triple-negative breast cancer and its relationship with prognosis

更新时间：2026-01-09

- Expression of programmed cell death gene 4 in triple-negative breast cancer and its relationship with prognosis
- Journal of Army Medical University Vol. 36, Issue 5, Pages: 495-498(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R195.4;R394.3;R737.9
- Published：2014
- 稿件说明：
移动端阅览
韩晓蓉,王颀,吴坤河,谢四梅,连臻强,黄宗海.三阴性乳腺癌中程序性细胞死亡基因4表达及其与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2014,36(05):495-498.

　Han Xiaorong,Wang Qi,Wu Kunhe,Xie Simei,Lian Zhenqiang,Huang Zonghai.Expression of programmed cell death gene 4 in triple-negative breast cancer and its relationship with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(05):495-498.
韩晓蓉,王颀,吴坤河,谢四梅,连臻强,黄宗海.三阴性乳腺癌中程序性细胞死亡基因4表达及其与预后的关系[J].陆军军医大学学报(原第三军医大学学报),2014,36(05):495-498. DOI：

　Han Xiaorong,Wang Qi,Wu Kunhe,Xie Simei,Lian Zhenqiang,Huang Zonghai.Expression of programmed cell death gene 4 in triple-negative breast cancer and its relationship with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(05):495-498. DOI：

摘要

目的探讨三阴性乳腺癌中程序性细胞死亡基因4（programmed cell death gene 4，PDCD4）的表达及其与患者预后的关系。方法收集广东省妇幼保健院乳腺科2007年1月至2012年12月间收治的随访资料完整的三阴性乳腺癌患者共176例，均为女性，中位年龄44岁。采用免疫组化方法检测PDCD4的表达；采用Kaplan-meier法对患者的无病生存及总生存情况进行分析，并运用Cox回归法探讨影响三阴性乳腺癌生存预后的因素。结果 176例患者中，PDCD4表达阳性者79例（44.8%），显著低于癌旁组织阳性表达率（90.0%，

=0.005）。PDCD4表达缺失与年龄无关(

0.05)，而与肿瘤直径、淋巴结转移个数及组织学分级相关(

0.05)，肿瘤越大（r=-0.270，

0.001）、淋巴结转移越多（r=-0.240，

=0.001）、组织学分级越高（r=-0.206，

=0.006），PDCD4阳性表达率越低。中位随访时间42个月，单因素分析显示PDCD4表达阳性者其无病生存率及总生存率均优于表达阴性者(

0.05)。多因素分析显示PDCD4表达、肿瘤直径及分期是影响三阴性乳腺癌预后的独立因素(

0.05)。结论三阴性乳腺癌中PDCD4表达缺失与预后不良相关，PDCD4可作为评估三阴性乳腺癌预后的指标。

Abstract

Objective Programmed cell death gene 4 (PDCD4) is a tumor suppressor gene

and plays an important role in regulation of cell apoptosis. The study was to investigate the expression of PDCD4 and its correlation with clinicopathological characteristics and prognosis of triple negative breast cancer. Methods A total of 176 patients with pathologically diagnosed triple-negative breast cancer and c

omplete follow-up data were subjected from Department of Breast Surgery in Guangdong Maternal and Children Hospital during Jan

2007 to Dec

2012

and all patients were women

with a median age of 44. PDCD4 expression in the 176 specimens and 10 specimens of para-tumor breast tissues was detected by S-P immunohistochemical assay. SPSS 13.0 statistical software was used to conduct Chi-square test

and Kaplan-meier and COX proportional hazards model was used to analyze the prognosis. Results The positive rate of PDCD4 in the tumor cells of triple negative breast cancer was significantly lower than that in the para-tumor breast tissues (44.8% vs 90.0%

=0.005). The loss of PDCD4 expression was closely correlated to tumor size (r=-0.270

0.001)

lymph node metastasis (r=-0.240

=0.001) and histological grade (r=-0.206

=0.006). The median follow-up period was 42 months. The disease free survival and overall survival rate was significantly higher in PDCD4-positive group than in PDCD4-negative group (

0.05). Cox model revealed that PDCD4 expression

tumor size

and stage were independent prognostic factors of triple-negative breast cancer (

0.05). Conclusion PDCD4 expression is down-regulated in triple-negative breast cancer

and the loss of PDCD4 expression is correlated to poor prognosis. PDCD4 is an independent prognostic factor of triple-negative breast cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A novel estrogen receptor expression stratification (low/moderate/high) based on Chinese population provides more accurate prognosis prediction for HR⁺/HER2^- early breast cancer patients

Immunosuppressive microenvironment of TGIF1-overexpressing gastric cancers and its clinical significance

Impact of molecular heterogeneity of NPM1 mutations on prognosis of acute myeloid leukemia: a clinical report of 86 cases

Association of 5-factor modified frailty index and controlling nutritional status score with overall survival in patients with unresectable hepatocellular carcinoma undergoing interventional therapy

Construction and validation of prediction model for cervical cancer recurrence based on systemic inflammation response index and clinicopathological parameters

Related Author

WANG Chengfang

ZHOU Yuqin

ZHANG Yanling

QI Xiaowei

ZHANG Yi

TONG Huyun

CHEN Xu

ZHANG Wenjie

Related Institution

Department of Breast and Thyroid Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Gastroenterology， Chongqing Hechuan District People’s Hospital

School of Medicine， Chongqing University

Chongqing Key Laboratory of Precision Prevention and Treatment for Digestive System Tumors， Department of Gastroenterology， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of Hematology, the First Hospital of Lanzhou University

⁰